Document Detail


Effect of GABA analogues on blood pressure and central GABA metabolism in the rat.
MedLine Citation:
PMID:  7435198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gamma aminobutyric acid (GABA) and different GABA analogues were examined for their cardiovascular actions and their influence on striatal dopamine (DA) levels and GABA accumulation after aminooxyacetic acid (AOAA). Gamma hydroxybutyric acid (GHBA) and baclofen caused hypertension and tachycardia after systemic as well as intracerebroventricular administration, while the opposite was true for GABA and muscimol. The hypertension after GHBA and baclofen was not reduced by picrotoxin or bicuculline and was not influenced by varying GABA levels by 3-mercaptopropionic acid (3-MPA) or AOAA. GHBA and muscimol but not baclofen reduced GABA accumulation induced by AOAA. Picrotoxin in a subconvulsive dose increased GABA accumulation and antagonized the inhibition after GHBA or muscimol. Bicuculline and a moderate dose of picrotoxin tended to decrease GABA accumulation by themselves and if anything augmented the effects of GHBA and muscimol. GHBA and baclofen but not muscimol in combination with AOAA increased DA levels, which was not prevented by picrotoxin or bicuculline. We conclude that the cardiovascular actions of GHBA and baclofen are probably not mediated by mechanisms identical to those of muscimol or exogenous GABA. In view of the biochemical results their actions would however be compatible with a concept of different GABA receptors.
Authors:
B Persson; M Henning
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  47     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3-Mercaptopropionic Acid / pharmacology
Aminooxyacetic Acid / pharmacology
Animals
Baclofen / pharmacology
Bicuculline / pharmacology
Blood Pressure / drug effects*
Brain / metabolism*
Dopamine / metabolism
Heart Rate / drug effects
Hydroxybutyrates / pharmacology
Male
Muscimol / pharmacology
Picrotoxin / pharmacology
Rats
Sodium Oxybate
gamma-Aminobutyric Acid / analogs & derivatives*,  metabolism*,  pharmacology
Chemical
Reg. No./Substance:
0/Hydroxybutyrates; 107-96-0/3-Mercaptopropionic Acid; 1134-47-0/Baclofen; 124-87-8/Picrotoxin; 2763-96-4/Muscimol; 485-49-4/Bicuculline; 502-85-2/Sodium Oxybate; 56-12-2/gamma-Aminobutyric Acid; 645-88-5/Aminooxyacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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