Document Detail


Effect of Fluosol-DA hemodilution on the kinetics of hepatically eliminated drugs.
MedLine Citation:
PMID:  3575876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of four hepatically eliminated drugs were determined in the rat following moderate hemodilution with either Fluosol-DA or normal saline. The drugs, antipyrine, phenytoin, indocyanine green, and d-propranolol, have extraction ratios from 0.01 to 0.99 in the rat. Animals received an intravenous dose of the drug 0.5, 24, 48, or 72 hours after hemodilution and drug disposition was compared to non-exchanged animals. Antipyrine clearance was increased 48 and 72 hours after Fluosol-DA exchange probably due to enhanced microsomal enzymatic activity. Indocyanine green clearance was decreased 24 hours after Fluosol-DA exchange more likely by a change in its extraction ratio than by alterations in hepatic blood flow. Phenytoin and d-propranolol clearances were decreased at 24 and 72 hours respectively after Fluosol-DA hemodilution due to a decreased apparent volume of distribution. Saline hemodilution decreased phenytoin clearance 24, 48, and 72 hours after exchange also by decreasing the apparent volume of distribution. This volume change was thought to be due to hypovolemia or a microcirculation redistribution which was secondary to hemodilution.
Authors:
R P Shrewsbury
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  55     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-12     Completed Date:  1987-06-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antipyrine / metabolism
Blood Substitutes / pharmacology*
Drug Combinations / pharmacology
Fluorocarbons / pharmacology*
Hemodilution*
Indocyanine Green / metabolism
Kinetics
Liver / drug effects,  metabolism*
Pharmaceutical Preparations / metabolism*
Phenytoin / metabolism
Propranolol / metabolism
Rats
Grant Support
ID/Acronym/Agency:
HL33227/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Drug Combinations; 0/Fluorocarbons; 0/Pharmaceutical Preparations; 3599-32-4/Indocyanine Green; 525-66-6/Propranolol; 57-41-0/Phenytoin; 60-80-0/Antipyrine; 75216-20-5/Fluosol-DA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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