| Effects of fluconazole, amphotericin B, and caspofungin on Candida albicans biofilms under conditions of flow and on biofilm dispersion. | |
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MedLine Citation:
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PMID: 21518839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have examined the effect of continuous perfusion with antifungals on Candida albicans biofilms under conditions of flow, closely mimicking physiological conditions encountered within patients. Biofilms displayed high levels of resistance to fluconazole, and this antifungal exerted minor effects on dispersion levels. Amphotericin B proved effective in reducing viability of cells within the biofilms and dispersion, but only at high concentrations. Under flow conditions, caspofungin exhibited potent activity against biofilms and drastically reduced biofilm dispersion. |
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Authors:
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Priya Uppuluri; Anand Srinivasan; Anand Ramasubramanian; Jose L Lopez-Ribot |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-04-25 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 55 ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-17 Completed Date: 2011-10-14 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 3591-3 Citation Subset: IM |
Affiliation:
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Department of Biology, South Texas Center for Emerging Infectious Diseases,The University of Texas at San Antonio, San Antonio, Texas 78249, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphotericin B
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pharmacology* Antifungal Agents / pharmacology* Biofilms / drug effects* Candida albicans / drug effects* Echinocandins / pharmacology* Fluconazole / pharmacology* Microbial Sensitivity Tests |
| Grant Support | |
ID/Acronym/Agency:
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R21AI080930/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Echinocandins; 0/caspofungin; 1397-89-3/Amphotericin B; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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