| Effect of Flow Aids on Mucoadhesive Properties of Polymeric Discs of Polyoxyethylene and Carbopol 971P. | |
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MedLine Citation:
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PMID: 20582205 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The aim of present study is to investigate the effect of flow aids on the observed in vitro mucoadhesion of two representative polymers; polyoxyethylene and Carbopol((R)) 971P. More recently it has been shown that the addition of small amounts of certain excipients to a mucoadhesive formulation can lead to a substantial decrease in observed mucoadhesion in an in vitro test system, which suggests that formulation of these systems could be crucial in developing successful dosage forms. A series of experiments has been carried out which indicates that the presence of flow aids at high concentrations present in tablets can affect the observed ex-vivo mucoadhesive bond. Magnesium stearate (5%) exerts its negative effect on the mucoadhesion of Carbopol((R)) 971P and polyoxyethylene combination by hindering the hydration of the polymer. Adhesion time of formulation containing 5% magnesium stearate was found 4.7+/-0.34 h and percent hydration of same formulation was 70.12%.Talc and colloidal silicon dioxide (Aerosil), which do not possess the same hydrophobic properties or have available divalent cations were found to be viable alternatives to magnesium stearate. |
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Authors:
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M H Bele; V V Gholap; O U Joshi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of pharmaceutical sciences Volume: 72 ISSN: 1998-3743 ISO Abbreviation: Indian J Pharm Sci Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-06-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7809431 Medline TA: Indian J Pharm Sci Country: India |
Other Details:
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Languages: eng Pagination: 128-9 Citation Subset: - |
Affiliation:
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NDMVPS's College of Pharmacy, Department of Pharmaceutics, Shivajinagar, Gangapur Road, Nashik-422 002, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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