Document Detail


Effect of feeding fescue seed containing ergot alkaloid toxins on stallion spermatogenesis and sperm cells.
MedLine Citation:
PMID:  22524585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cellular effects of tall fescue grass-associated toxic ergot alkaloids on stallion sperm and colt testicular tissue were evaluated. This was a continuation of an initial experiment where the effects of toxic ergot alkaloids on the stallion spermiogram were investigated. The only spermiogram parameter in exposed stallions that was affected by the toxic ergot alkaloids was a decreased gel-free volume of the ejaculate. This study examined the effect of toxic ergot alkaloids on chilling and freezing of the stallion sperm cells. The effect of toxic ergot alkaloids on chilled extended sperm cells for 48 h at 5°C was to make the sperm cells less likely to undergo a calcium ionophore-induced acrosome reaction. The toxic ergot alkaloids had no effect on the freezability of sperm cells. However, if yearling colts were fed toxic ergot alkaloids, then the cytological analysis of meiotic chromosome synapsis revealed a significant increase in the proportion of pachytene spermatocytes showing unpaired sex chromosomes compared to control spermatocytes. There was little effect of ergot alkaloids on adult stallions, but there might be a significant effect on yearling colts.
Authors:
R Fayrer-Hosken; A Stanley; N Hill; G Heusner; M Christian; R De La Fuente; C Baumann; L Jones
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-04-24
Journal Detail:
Title:  Reproduction in domestic animals = Zuchthygiene     Volume:  47     ISSN:  1439-0531     ISO Abbreviation:  Reprod. Domest. Anim.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-03     Revised Date:  2013-12-06    
Medline Journal Info:
Nlm Unique ID:  9015668     Medline TA:  Reprod Domest Anim     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1017-26     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Verlag GmbH.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed / analysis*
Animal Nutritional Physiological Phenomena
Animals
Cryopreservation / veterinary
Diet / veterinary
Ergot Alkaloids / chemistry,  toxicity*
Freezing
Horses / physiology*
Male
Poaceae / chemistry*
Seeds / chemistry*
Semen
Semen Analysis / veterinary
Semen Preservation
Spermatogenesis / drug effects*
Spermatozoa / cytology,  drug effects
Grant Support
ID/Acronym/Agency:
2R01-HD042740/HD/NICHD NIH HHS; R01 HD042740/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Ergot Alkaloids
Comments/Corrections

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