| The Effect of Ezetimibe and Simvastatin on Monocyte Cytokine Release In Patients With Isolated Hypercholesterolemia. | |
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MedLine Citation:
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PMID: 21297492 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Apart from reducing plasma lipids, ezetimibe may produce non-lipid-related pleiotropic effects. The aim of this paper was to compare the effect of ezetimibe and simvastatin on monocyte cytokine release and systemic inflammation in isolated hypercholesterolemic patients. One hundred thirty-four subjects with isolated hypercholesterolemia were allocated into one of four treatment groups treated for 90 days with respectively ezetimibe, simvastatin, ezetimibe plus simvastatin, or placebo. Monocyte cytokine release was determined at baseline and after 30 and 90 days of treatment. Compared to placebo, all the remaining treatment options reduced monocyte release of tumor necrosis factor-α, interleukin-1β, interleukin-6 and monocyte chemoattractant protein-1, which was accompanied by a reduction in plasma C-reactive protein (CRP) levels. In subjects receiving both simvastatin and ezetimibe, post-treatment monocyte cytokine release and plasma CRP levels did not differ from those observed in 30 matched healthy subjects. Monocyte-suppressing and systemic-anti-inflammatory effects were more expressed in simvastatin- than in ezetimibe-treated patients, and strongest when both the agents were administered together. The obtained results suggest that simvastatin may be a better treatment option than ezetimibe in isolated hypercholesterolemic patients and that hypercholesterolemic patients of high cardiovascular risk may benefit the most from combined treatment with simvastatin and ezetimibe. |
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Authors:
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Robert Krysiak; Boguslaw Okopien |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-03 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: - ISSN: 1533-4023 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, PL 40-752 Katowice, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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