Document Detail

Effect of Exercise Training in Patients With Chronic Obstructive Pulmonary Disease Compared With Healthy Elderly Subjects.
MedLine Citation:
PMID:  22487615     Owner:  NLM     Status:  Publisher    
PURPOSE:: Exercise training in patients with chronic obstructive pulmonary disease (COPD) can be challenging because whole-body exercise often elicits disabling symptoms of dyspnea before the exercising muscles reach their critical limits. The extent that this factor limits training has not been totally defined. The purpose of this study was to compare the response to training of patients with moderate to severe COPD with that achieved by healthy elderly subjects who were exercising using an identical program. METHODS:: Eight healthy subjects and 20 patients with COPD (forced expiratory volume in 1 second 42 ± 13% predicted) exercised 3 times a week for 8 weeks. Outcome measures included 6-minute walk distance, maximal exercise capacity (Wmax) during an incremental cycle ergometer test, and submaximal constant workload (60%-70% of subject Wmax) exercise time. RESULTS:: Six-minute walk distance and Wmax increased after training to a significantly greater extent in the healthy controls compared with the patients with COPD; 65 ± 24 versus 32 ± 50 m, P = .03; and 25.1±13.9 versus 11.5±13.1 watts, P = .025, respectively. However, these differences disappeared when data were expressed as percent improvement, 12.1 ± 5.3% versus 10.0 ± 15.8%, and 25.6 ± 13.5% versus 23.1 ± 33.3%. Improvement in submaximal constant workload exercise time after training was similar in healthy controls 21.6 ± 6.1 versus patients with COPD 18.8 ± 11.2 minutes. CONCLUSIONS:: Patients with COPD can show similar relative improvements in exercise capacity compared with healthy elderly subjects. The difference in absolute values reflects, at least in part, the greater baseline exercise capacity.
M Jeffery Mador; Matthew Krauza; Mary Shaffer
Related Documents :
3753395 - Effect of calmodulin antagonists on hypoxia and reoxygenation damage in isolated rabbit...
10487295 - How newborn mammals cope with hypoxia.
14991325 - Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance...
5101295 - Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altit...
6241785 - Ventricular fibrillation threshold in the three-toed sloth (bradypus tridactylus).
3141015 - Differences in basal and postexercise osteocalcin levels in athletic and nonathletic hu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-6
Journal Detail:
Title:  Journal of cardiopulmonary rehabilitation and prevention     Volume:  -     ISSN:  1932-751X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101291247     Medline TA:  J Cardiopulm Rehabil Prev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Veterans Affairs Western New York Healthcare System (Dr Mador and Ms Shaffer) and Division of Pulmonary, Critical Care and Sleep Medicine, State University of New York at Buffalo (Drs Mador and Krauza), Buffalo.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Can Individuals Participating in Cardiac Rehabilitation Achieve Recommended Exercise Training Levels...
Next Document:  Patients With Heart Failure in the "Intermediate Range" of Peak Oxygen Uptake: ADDITIVE VALUE OF HEA...