Document Detail

Effect of exercise and respiratory training on clinical progression and survival in patients with severe chronic pulmonary hypertension.
MedLine Citation:
PMID:  21311162     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Even though specific agents for the treatment of patients with pulmonary hypertension (PH) are available, in PH patients, physical capacity and quality of life (QoL) are often restricted and survival is reduced.
OBJECTIVES: This study prospectively investigated the long-term effects of respiratory and exercise training in patients with severe chronic PH regarding safety, time to clinical worsening and survival.
METHODS: Fifty-eight consecutive patients with severe PH on stable disease-targeted medication received exercise and respiratory training in hospital for 3 weeks and continued at home. They were prospectively followed for 24 ± 12 months. Primary endpoints were time to clinical worsening and survival. Adverse events and changes in the 6-min walking test, QoL, WHO functional class and gas exchange were secondary endpoints and were evaluated at baseline and at weeks 3 and 15.
RESULTS: All patients tolerated the exercise training well without severe adverse events. In week 15, 6-min walking test results were significantly improved compared to baseline (by 84 ± 49 m, p < 0.001), as well as QoL scores, WHO functional class (from 2.9 ± 0.5 to 2.6 ± 0.6, p < 0.01), peak oxygen consumption (from 12.5 ± 3.0 to 14.6 ± 3.9 ml/min/kg, p < 0.001), heart rate at rest (from 75 ± 12 to 61 ± 18 beats/min, p < 0.001) and maximal workload (from 65 ± 21 to 80 ± 25 W, p < 0.001). Survival at 1 and 2 years was 100 and 95%, respectively. Fifteen events occurred during the follow-up.
CONCLUSION: This study indicates that exercise and respiratory training as add-on to medical treatment may improve exercise capacity and QoL, and that they have a good long-term safety in the described setting.
Ekkehard Grünig; Nicola Ehlken; Ardeschir Ghofrani; Gerd Staehler; F Joachim Meyer; Jana Juenger; Christian F Opitz; Hans Klose; Heinrike Wilkens; Stephan Rosenkranz; Horst Olschewski; Michael Halank
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-09
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  81     ISSN:  1423-0356     ISO Abbreviation:  Respiration     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-08-18     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  394-401     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
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MeSH Terms
Chronic Disease
Disease Progression
Exercise Therapy*
Heart Failure / epidemiology
Heart Rate
Hypertension, Pulmonary / epidemiology,  mortality*,  rehabilitation,  therapy*
Middle Aged
Oxygen / blood
Prospective Studies
Quality of Life
Respiratory Therapy*
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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