Document Detail


Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study.
MedLine Citation:
PMID:  23213072     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Physical activity is associated with improved breast cancer survival, but the underlying mechanisms, possibly including modification of the inflammatory state, are not well understood. We analyzed changes in interleukin (IL)-6, C-reactive protein (CRP), and TNF-α in a randomized controlled trial of exercise in postmenopausal breast cancer survivors. Seventy-five women, recruited through the Yale-New Haven Hospital Tumor Registry, were randomized to either a six-month aerobic exercise intervention or usual care. Correlations were calculated between baseline cytokines, adiposity, and physical activity measures. Generalized linear models were used to assess the effect of exercise on IL-6, CRP, and TNF-α. At baseline, IL-6 and CRP were positively correlated with body fat and body mass index (BMI) and were inversely correlated with daily pedometer steps (P < 0.001). We found no significant effect of exercise on changes in inflammatory marker concentrations between women randomized to exercise versus usual care, though secondary analyses revealed a significant reduction in IL-6 among exercisers who reached 80% of the intervention goal compared with those who did not. Future studies should examine the effect of different types and doses of exercise and weight loss on inflammatory markers in large-scale trials of women diagnosed with breast cancer.
Authors:
Sara B Jones; Gwendolyn A Thomas; Sara D Hesselsweet; Marty Alvarez-Reeves; Herbert Yu; Melinda L Irwin
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-04
Journal Detail:
Title:  Cancer prevention research (Philadelphia, Pa.)     Volume:  6     ISSN:  1940-6215     ISO Abbreviation:  Cancer Prev Res (Phila)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-19     Revised Date:  2014-04-09    
Medline Journal Info:
Nlm Unique ID:  101479409     Medline TA:  Cancer Prev Res (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-18     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood*
Breast Neoplasms / blood*,  complications,  mortality
C-Reactive Protein / analysis
Carcinoma / blood*,  complications,  mortality
Exercise / physiology*
Female
Humans
Inflammation / blood*,  complications,  metabolism
Interleukin-6 / analysis,  blood
Middle Aged
Survival Rate
Survivors
Tumor Necrosis Factor-alpha / analysis,  blood
Grant Support
ID/Acronym/Agency:
M01-RR00125/RR/NCRR NIH HHS; T32 HL007055/HL/NHLBI NIH HHS; T32 NR008346/NR/NINR NIH HHS; T32 NR008346/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein
Comments/Corrections

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