Document Detail

Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes.
MedLine Citation:
PMID:  20467191     Owner:  NLM     Status:  MEDLINE    
AIM: The effects of exercise intervention and to assess its long-term efficacy in preventing subsequent cardiovascular events in patients with type 2 diabetes were little known on randomized controlled trial.
METHODS: Thirty-eight type 2 diabetic patients (21 men and 17 women) were assigned to either the exercise group (n=21) or the control group without exercise training (n=17) by simple randomization. The exercise training group was scheduled for aerobic and resistance exercise programs for 3 months. After the 3-month, we investigated endothelial function, insulin resistance, adipocytokines and inflammatory markers. The endothelial function was evaluated by examining a flow-mediated endothelium-dependent vasodilatation (FMD). Furthermore, we followed the incidence of cardiovascular events for 24 months.
RESULTS: After 3-month, HbA1C was decreased significantly in both groups. FMD was increased from 7.3+/-4.7% to 10.9+/-6.2% only in the exercise group (p<0.05). Long-term follow-up data showed that the control group developed cardiovascular events more frequently than did the exercise group (p<0.05).
CONCLUSIONS: Exercise improves endothelial dysfunction independently of glycemic control and insulin sensitivity in patients with type 2 diabetes. The beneficial effects of 3-month exercise to reduce cardiovascular events persist for 24 months.
Sadanori Okada; Aki Hiuge; Hisashi Makino; Ayako Nagumo; Hiroshi Takaki; Harumi Konishi; Yoichi Goto; Yasunao Yoshimasa; Yoshihiro Miyamoto
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-05-13
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  17     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  828-33     Citation Subset:  IM    
Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Suita, Osaka, Japan.
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MeSH Terms
Blood Glucose / metabolism
Blood Pressure
Cardiovascular Diseases / etiology,  metabolism,  therapy*
Diabetes Mellitus, Type 2 / complications,  metabolism,  therapy*
Endothelium, Vascular / metabolism*
Exercise Therapy*
Follow-Up Studies
Hemoglobin A, Glycosylated / metabolism
Insulin Resistance
Intervention Studies
Middle Aged
Vasodilation / physiology
Reg. No./Substance:
0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human

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