| Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 20467191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The effects of exercise intervention and to assess its long-term efficacy in preventing subsequent cardiovascular events in patients with type 2 diabetes were little known on randomized controlled trial. METHODS: Thirty-eight type 2 diabetic patients (21 men and 17 women) were assigned to either the exercise group (n=21) or the control group without exercise training (n=17) by simple randomization. The exercise training group was scheduled for aerobic and resistance exercise programs for 3 months. After the 3-month, we investigated endothelial function, insulin resistance, adipocytokines and inflammatory markers. The endothelial function was evaluated by examining a flow-mediated endothelium-dependent vasodilatation (FMD). Furthermore, we followed the incidence of cardiovascular events for 24 months. RESULTS: After 3-month, HbA1C was decreased significantly in both groups. FMD was increased from 7.3+/-4.7% to 10.9+/-6.2% only in the exercise group (p<0.05). Long-term follow-up data showed that the control group developed cardiovascular events more frequently than did the exercise group (p<0.05). CONCLUSIONS: Exercise improves endothelial dysfunction independently of glycemic control and insulin sensitivity in patients with type 2 diabetes. The beneficial effects of 3-month exercise to reduce cardiovascular events persist for 24 months. |
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Authors:
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Sadanori Okada; Aki Hiuge; Hisashi Makino; Ayako Nagumo; Hiroshi Takaki; Harumi Konishi; Yoichi Goto; Yasunao Yoshimasa; Yoshihiro Miyamoto |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-05-13 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 17 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 828-33 Citation Subset: IM |
Affiliation:
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Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Suita, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Glucose / metabolism Blood Pressure Cardiovascular Diseases / etiology, metabolism, therapy* Diabetes Mellitus, Type 2 / complications, metabolism, therapy* Endothelium, Vascular / metabolism* Exercise Therapy* Female Follow-Up Studies Hemoglobin A, Glycosylated / metabolism Humans Incidence Insulin Resistance Intervention Studies Male Middle Aged Vasodilation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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