Document Detail


Effect of exercise and heat-induced hypohydration on brain volume.
MedLine Citation:
PMID:  20421835     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: The aim of this study was to quantify changes in brain volume after exercise/heat-induced hypohydration in man.
METHODS: Eight active men completed intermittent exercise in a warm environment, until 2.9% ± 0.1% of body mass was lost. Subjects remained hypohydrated for 2 h after the end of exercise. Brain volume was measured before, immediately after, and 1 and 2 h after exercise using magnetic resonance imaging (Philips 3T Achieva, AE Eindhoven, The Netherlands). Measures of subjective feelings and core body temperature were also monitored. Blood samples were drawn to determine serum electrolyte concentrations and osmolality and to allow calculation of changes in blood and plasma volumes.
RESULTS: Brain volume was not influenced by hypohydration (0.2% ± 0.4%; effect size (ES) = 0.2, P = 0.310). Reductions in ventricular (4.0% ± 1.8%; ES = 4.6, P < 0.001) and cerebrospinal fluid (3.1% ± 1.9%; ES = 3.3, P = 0.003) volumes were observed after exercise. Compared with preexercise levels, serum osmolality was elevated throughout the 2-h postexercise period (+10 ± 2 mOsm·kg, P < 0.001). Core temperature increased from 37.1°C ± 0.3°C at rest to 39.3°C ± 0.5°C at the end of exercise (P = 0.001).
CONCLUSIONS: These data demonstrate that brain volume remains unchanged in response to moderate hypohydration and presence of serum hyperosmolality, suggesting that mechanisms are in place to defend brain volume.
Authors:
Phillip Watson; Kay Head; Alain Pitiot; Peter Morris; Ronald J Maughan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  42     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2197-204     Citation Subset:  IM; S    
Affiliation:
School of Sport, Exercise and Health Sciences, Loughborough University, Leicestershire, United Kingdom.
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