Document Detail

Effect of Escherichia coli endotoxin on dog lung fluid balance.
MedLine Citation:
PMID:  6344656     Owner:  NLM     Status:  MEDLINE    
Endotoxin may cause an increase in pulmonary capillary permeability and thus promote edema formation. We used a gravimetric technique to estimate the pulmonary capillary filtration coefficient (KF) and the maximum capillary pressure at which the lung could maintain a constant weight (Pccritical) in dogs after intravenous administration of Escherichia coli (E. coli) endotoxin. KF should be increased and Pccritical should be decreased by an increase in permeability. Four groups of three to four dogs were given 1, 10, 1,000, or 3,000 micrograms/kg of endotoxin. A fifth group of five dogs, which served as controls, was given no endotoxin. KF was significantly (P less than 0.05) greater than control [0.049 +/- 0.031 (SD) ml . min-1 . mmHg-1] in only the 1-micrograms/kg group (0.100 +/- 0.027), indicating a possible increase in permeability. However, changes in capillary surface area may have affected KF. Pccritical was not significantly different from control (20.7 +/- 2.4 mmHg) in any of the E. coli groups. We conclude from these results that E. coli endotoxin may have caused a slight increase in permeability; however, the lung retained its ability to resist edema formation.
R L Scott; D K Adcock; R E Drake; J C Gabel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  244     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H763-8     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Blood Proteins / analysis
Body Water / physiology*
Cardiac Output / drug effects
Endotoxins / pharmacology*
Escherichia coli*
Heart Rate / drug effects
Lung / physiology*
Pulmonary Circulation / drug effects*
Vascular Resistance / drug effects
Grant Support
Reg. No./Substance:
0/Blood Proteins; 0/Endotoxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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