Document Detail


Effect of Epothilone B on Cell Cycle, Metabolic Activity, and Apoptosis Induction on Human Epithelial Cancer Cells-Under Special Attention of Combined Treatment With Ionizing Radiation.
MedLine Citation:
PMID:  22909073     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In recent studies, epothilone B was shown to have a cytotoxic and radiosensitizing effect on cells. The aim of our investigation was to explain this impact by examining the mode of action of epothilone B on FaDu and A549 tumor cells. Flow cytometry was used for cell cycle distribution and for the evaluation of apoptosis. Metabolic activity was studied by proliferation assay. Influence on nuclei morphology was investigated by DNA-staining. We showed that epothilone B-induced G2/M accumulation is the main rationale for drug-induced radiosensitivity. The cytotoxic effect resulted in apoptotic cell death, decreased metabolic activity, and formation of multinucleated cells.
Authors:
Tonja Baumgart; Stephan Kriesen; Guido Hildebrandt; Katrin Manda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Cancer investigation     Volume:  -     ISSN:  1532-4192     ISO Abbreviation:  Cancer Invest.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Radiotherapy and Radiation Oncology, University of Rostock, Rostock, Germany.
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