| Effect of epinephrine and insulin resistance on human monocytes obtained from lean and obese healthy participants: a pilot study. | |
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MedLine Citation:
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PMID: 20682615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the effect of epinephrine on human monocytes. Monocytes were isolated from 16 healthy obese and 10 lean healthy subjects. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. Obese subjects were subdivided into 2 sub-groups, insulin sensitive (IS) and insulin resistant (IR). Monocyte properties [attachment to laminin 1, migration through laminin 1, oxidized-low density lipoprotein (oxLDL) phagocytosis] were assessed pre- and post-stimulation in vitro with epinephrine. Experiments were repeated after incubation with a Na(+)/H( +) exchanger-1 inhibitor (NHE-1) (cariporide). Epinephrine increased monocyte attachment to laminin in lean and obese IR subjects through involvement of NHE-1, PKC, NO synthase, NADPH oxidase and actin polymerization. In contrast, epinephrine did not affect monocyte migration. Epinephrine increased oxLDL phagocytosis in all groups studied. Incubation with cariporide attenuated oxLDL phagocytosis. Epinephrine induces monocyte dysfunction which may be atherogenic. |
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Authors:
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Maria Sarigianni; Eleni Bekiari; Apostolos Tsapas; Diamantis Konstantinidis; Martha Kaloyianni; George Koliakos; Konstantinos Paletas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-03 |
Journal Detail:
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Title: Angiology Volume: 62 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-07 Completed Date: 2011-01-06 Revised Date: 2011-06-28 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 38-45 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Aristotle University of Thessaloniki, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Epinephrine / pharmacology* Female Humans Insulin Resistance* Male Monocytes / drug effects*, physiology* Obesity / blood* Pilot Projects Thinness / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
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51-43-4/Epinephrine |
| Comments/Corrections | |
Comment In:
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Angiology. 2011 May;62(4):349
[PMID:
21474469
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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