| Effect of Different Obesogenic Diets on Pancreatic Histology in Ossabaw Miniature Swine. | |
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MedLine Citation:
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PMID: 21240032 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: Obesity is a factor in the outcome and severity of pancreatic conditions. We examined the effect of hypercaloric diets on the pancreata of Ossabaw swine, a large animal model of metabolic syndrome and obesity. METHODS:: Swine were fed with 1 of 4 diets: high-fructose (n = 9), atherogenic (n = 10), modified atherogenic (n = 6), or eucaloric standard diet (n = 12) for 24 weeks. Serum chemistries were measured, and pancreata were examined for histological abnormalities including steatosis, inflammation or fibrosis, insulin content, and oxidative stress. RESULTS:: The fructose, atherogenic, and modified atherogenic diet groups exhibited obesity, metabolic syndrome, islet enlargement, and significantly increased pancreatic steatosis (22.9% ± 7.5%, 19.7% ± 7.7%, and 38.7% ± 15.3% fat in total tissue area, respectively) compared with controls (9.3% ± 1.9%; P < 0.05). The modified atherogenic diet group showed significantly increased oxidative stress levels as evidenced by elevated serum malondialdehyde (3.0 ± 3.3 vs 1.5 ± 0.3 μmol/L in controls; P = 0.006) and pancreatic malondialdehyde (0.1 ± 0.12 vs 0.04 ± 0.01 nmol/mg protein in controls; P = 0.01). None of the swine exhibited pancreatitis or cellular injury. CONCLUSIONS:: Ossabaw swine fed with a modified atherogenic diet developed significant pancreatic steatosis and increased oxidative stress, but no other histological abnormalities were observed. |
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Authors:
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Allison M Fullenkamp; Lauren N Bell; Reiesha D Robbins; Lydia Lee; Romil Saxena; Mouhamad Alloosh; James E Klaunig; Raghavendra G Mirmira; Michael Sturek; Naga Chalasani |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-12 |
Journal Detail:
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Title: Pancreas Volume: - ISSN: 1536-4828 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Divisions of Gastroenterology/Hepatology, and †Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN; ‡Department of Pharmacology, University of Virginia, Charlottesville, VA; §Departments of Pathology and Laboratory Medicine, ∥Cellular & Integrative Physiology, ¶Toxicology, and #Pediatrics, Indiana University School of Medicine, Indianapolis, IN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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