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Effect of Different Levels of Docosahexaenoic Acid Supply on Fatty Acid Status and Linoleic and α-Linolenic Acid Conversion in Preterm Infants: A Randomized Clinical Trial.
MedLine Citation:
PMID:  22008957     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: LC-PUFA enrichment of preterm infant formulas is recommended to meet high demands. Dietary LC-PUFA might inhibit endogenous LC-PUFA synthesis thus limiting their benefit. We investigated effects of different docosahexaenoic acid (DHA) intakes on plasma and erythrocyte fatty acids and endogenous LC-PUFA synthesis in preterm infants. METHODS:: Fortytwo preterm infants (birthweight 1000-2200 g) were randomized double-blind to preterm formulas with γ-linolenic acid (GLA, 0.4%) and arachidonic acid (AA, 0.1%) but different DHA contents (A: 0.04%, B: 0.33%, C: 0.52%), 24 received human milk (HM: 0.51% AA, 0.38% DHA, non-randomized). Blood was sampled on study days 0, 14 and 28. Uniformly C-labelled linoleic acid (2 mg*kg) and α-linolenic acid (1 mg*kg) were applied orally on day 26 and blood samples collected 48 hours later. RESULTS:: On day 28 group A had the lowest and group C the highest plasma phospholipid concentrations of eicosapentaenoic acid and DHA. Erythrocyte phospholipid DHA was lowest in group A, but comparable in groups B, C and HM. Plasma and erythrocyte AA were lower in formula groups than in HM. DHA intake had no impact on DHA synthesis. LC-PUFA synthesis was lower in HM infants. CONCLUSIONS:: DHA supply dose dependently increased plasma DHA. Formula DHA levels of 0.33% matched plasma DHA status of infants fed HM. LC-PUFA synthesis was lower in infants fed HM than formulas with different DHA and low AA contents. With the LC-PUFA supplementation used, DHA in formulas did not inhibit AA or DHA synthesis.
Ulrike C Sauerwald; Maria M Fink; Hans Demmelmair; Patrick V Schoenaich; Astrid A M Rauh-Pfeiffer; Berthold Koletzko
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-15
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Kinderklinik and Kinderpoliklinik, Dr. von Hauner Children[Combining Acute Accent]s Hospital, University of Munich Medical Centre, München, Germany †Department of Paediatrics, Zentralklinikum Augsburg, Germany.
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