| Effect of Dietary Omega-3 Fatty Acids on the Heart Rate and the Heart Rate Variability Response to Myocardial Ischemia or Submaximal Exercise. | |
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MedLine Citation:
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PMID: 21460198 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) has been reported to decrease resting heart rate (HR) and increase heart rate variability (HRV). However, the effects of n-3 PUFAs on these variables in response to a physiological stress (e.g., exercise or acute myocardial ischemia), particularly in post myocardial infarction (MI) patients, are unknown. Therefore, HR and HRV (high frequency and total R-R interval variability) were evaluated at rest, during submaximal exercise, and during a 2 min coronary artery occlusion at rest, before and 3 months after n-3 PUFA treatment in dogs with healed MI (n = 59). The dogs were randomly assigned to either placebo (1 g/day, corn oil, n = 19) or n-3 PUFAs supplement (docosahexaenoic acid + eicosapentaenoic acid ethyl esters, 1g/day n = 6; 2 g/day, n = 12; or 4 g/day, n = 22) groups. The treatment elicited significant (P<0.01) dose-dependent increases in right atrial n-3 PUFA levels but dose-independent reductions in resting HR and increases in resting HRV. In contrast, n-3 PUFAs did not attenuate the large changes in HR or HRV induced by either the coronary occlusion or submaximal exercise. These data demonstrate that dietary n-3 PUFA decreased resting (i.e., pre-exercise or pre-occlusion) HR and increased resting HRV but did not alter the cardiac response to physiologic challenges. |
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Authors:
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George E Billman; William S Harris |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-1 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Ohio State University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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