| Effect of diet with and without exercise training on markers of inflammation and fat distribution in overweight women. | |
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MedLine Citation:
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PMID: 21183937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The independent effects of exercise and weight loss on markers of inflammation (MOI) in obese individuals have not been clearly characterized. The objectives of this study were to: (i) identify the independent effects of exercise and weight loss on MOI and (ii) determine whether changes in MOI were associated with changes in fat distribution. Subjects were 126 healthy, premenopausal women, BMI 27-30 kg/m(2). They were randomized to one of three groups: diet only, diet + aerobic-, or diet + resistance training until a BMI <25 kg/m(2) was achieved. Fat distribution was measured with computed tomography, and body composition with dual-energy X-ray absorptiometry. Serum concentrations of tumor necrosis factor (TNF)-α, soluble TNF receptor 1 (sTNF-R1), soluble TNF receptor 2 (sTNF-R2), C-reactive protein (CRP), and interleukin (IL)-6 were assessed. Results of repeated-measures ANOVA indicated a significant effect of time on MOI, such that MOI decreased with weight loss. Results of mixed-model analysis indicated that adjusting for intra-abdominal adipose tissue (IAAT) and total fat mass explained the decreases in TNF-α and sTNF-R1, whereas only total fat mass explained the decreases in sTNF-R2, IL-6, and CRP. In conclusion, weight loss was associated with decreases in MOI. The effect of weight loss appeared to be mediated by changes in total fat mass or IAAT. Addition of exercise did not alter the response, suggesting that weight loss has a more profound impact for reducing MOI in overweight women than exercise. |
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Authors:
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Gordon Fisher; Tanya C Hyatt; Gary R Hunter; Robert A Oster; Renee A Desmond; Barbara A Gower |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-12-23 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 19 ISSN: 1930-739X ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-25 Completed Date: 2011-09-13 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1131-6 Citation Subset: IM |
Affiliation:
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Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA. grdnfs@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity Adult Body Fat Distribution* Body Mass Index C-Reactive Protein / analysis Cytokines / blood Diet, Reducing* Exercise* Female Humans Inflammation Mediators / blood* Intra-Abdominal Fat / immunology Overweight / blood, diet therapy*, immunology*, therapy Receptors, Cytokine / blood, chemistry Resistance Training Solubility Time Factors Weight Loss Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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2T32DK062710-07/DK/NIDDK NIH HHS; M01-RR-00032/RR/NCRR NIH HHS; P30-DK56336/DK/NIDDK NIH HHS; P60DK079626/DK/NIDDK NIH HHS; R01 DK049779/DK/NIDDK NIH HHS; R01 DK049779-08/DK/NIDDK NIH HHS; R01 DK049779-09/DK/NIDDK NIH HHS; R01 DK049779-09S1/DK/NIDDK NIH HHS; R01 DK049779-09S2/DK/NIDDK NIH HHS; R01 DK049779-10/DK/NIDDK NIH HHS; R01DK49779/DK/NIDDK NIH HHS; R01DK51684/DK/NIDDK NIH HHS; T32 DK062710/DK/NIDDK NIH HHS; UL 1RR025777/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Inflammation Mediators; 0/Receptors, Cytokine; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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