Document Detail

Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women.
MedLine Citation:
PMID:  21494229     Owner:  NLM     Status:  MEDLINE    
Lifestyle interventions for weight loss are the cornerstone of obesity therapy, yet their optimal design is debated. This is particularly true for postmenopausal women; a population with a high prevalence of obesity yet toward whom fewer studies are targeted. We conducted a year-long, 4-arm randomized trial among 439 overweight-to-obese postmenopausal sedentary women to determine the effects of a calorie-reduced, low-fat diet (D), a moderate-intensity, facility-based aerobic exercise program (E), or the combination of both interventions (D+E), vs. a no-lifestyle-change control (C) on change in body weight and composition. The group-based dietary intervention had a weight-reduction goal of ≥10%, and the exercise intervention consisted of a gradual escalation to 45-min aerobic exercise 5 day/week. Participants were predominantly non-Hispanic whites (85%) with a mean age of 58.0 ± 5.0 years, a mean BMI of 30.9 ± 4.0 kg/m(2) and an average of 47.8 ± 4.4% body fat. Baseline and 12-month weight and adiposity measures were obtained by staff blinded to participants' intervention assignment. Three hundred and ninety nine women completed the trial (91% retention). Using an intention-to-treat analysis, average weight loss at 12 months was -8.5% for the D group (P < 0.0001 vs. C), -2.4% for the E group (P = 0.03 vs. C), and -10.8% for the D+E group (P < 0.0001 vs. C), whereas the C group experienced a nonsignificant -0.8% decrease. BMI, waist circumference, and % body fat were also similarly reduced. Among postmenopausal women, lifestyle-change involving diet, exercise, or both combined over 1 year improves body weight and adiposity, with the greatest change arising from the combined intervention.
Karen E Foster-Schubert; Catherine M Alfano; Catherine R Duggan; Liren Xiao; Kristin L Campbell; Angela Kong; Carolyn E Bain; Ching-Yun Wang; George L Blackburn; Anne McTiernan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-04-14
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  20     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-26     Completed Date:  2012-11-29     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1628-38     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue
Body Composition*
Body Mass Index
Caloric Restriction
Diet, Fat-Restricted
Intention to Treat Analysis
Life Style*
Middle Aged
Obesity / diet therapy,  therapy*
Patient Dropouts
Waist Circumference
Weight Loss*
Weight Reduction Programs
Grant Support
5KL2RR025015-03/RR/NCRR NIH HHS; KL2 RR025015/RR/NCRR NIH HHS; P30 CA015704/CA/NCI NIH HHS; R01 CA102504/CA/NCI NIH HHS; R01 CA102504/CA/NCI NIH HHS; R01 CA105204/CA/NCI NIH HHS; R25 CA057699/CA/NCI NIH HHS; R25 CA094880/CA/NCI NIH HHS; R25 CA94880/CA/NCI NIH HHS; U54 CA116847/CA/NCI NIH HHS; U54-CA116847/CA/NCI NIH HHS

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