Document Detail


Effect of Dai-kenchu-to on gastrointestinal motility based on differences in the site and timing of administration.
MedLine Citation:
PMID:  17404886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to investigate the effects of the herbal medicine dai-kenchu-to on gastrointestinal motility based on differences in the administration site and timing. We sutured strain-gauge transducers to the stomach (three), duodenum (one), jejunum (one), ileum (one), and colon (two) and inserted indwelling tubes into the stomach, jejunum, and proximal colon of beagles. Dai-kenchu-to was administered to each site during the fasting or fed state. During the fasting state, the prokinetic effects of dai-kenchu-to were evident at all administration sites. The effects were attenuated during the fed state. With intracolonic administration, a contraction similar to the giant migrating contraction-like contraction was induced during the fasting and the fed state, and defecation occurred. Despite the differences in administration site and timing, no contraction complex appeared orad to the administration sites. These results indicate that the prokinetic effects of dai-kenchu-to differ with the site or timing of administration.
Authors:
Naruo Kawasaki; Koji Nakada; Tomoko Nakayoshi; Yoshiyuki Furukawa; Yutaka Suzuki; Nobuyoshi Hanyu; Katsuhiko Yanaga
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Publication Detail:
Type:  Journal Article     Date:  2007-04-03
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  52     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-06     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2684-94     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan. naruk@jikei.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Automatic Data Processing
Colon
Dogs
Drug Administration Routes
Drug Administration Schedule
Duodenum
Follow-Up Studies
Gastrointestinal Motility / drug effects*,  physiology
Jejunum
Plant Extracts / administration & dosage*
Stomach
Telemetry / methods
Chemical
Reg. No./Substance:
0/Plant Extracts; 0/dai-kenchu-to

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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