Document Detail

Effect of DETA-NONOate and papaverine on vasodilation of human internal mammary artery.
MedLine Citation:
PMID:  22117187     Owner:  NLM     Status:  Publisher    
In this study, the relaxatory effect of DETA-NONOate is compared with that of papaverine on isolated human internal mammary artery. We investigated the inhibitory effects of DETA-NONOate and papaverine on phenylephrine-induced contractile response in internal mammary artery segments. The internal mammary artery segments, taken from methodologically matched patients who underwent coronary artery bypass grafting, were prepared, placed in an organ bath, and contracted with phenylephrine (10(-9) to 10(-4) mol/L) to investigate their relaxatory response to DETA-NONOate or papaverine. Phenylephrine dose-response contraction was obtained after 1, 2, and 3 h in segments pre-incubated with DETA-NONOate or papaverine for 30 min. The EC(50) that presented for internal mammary artery segments incubated with DETA-NONOate was 3.523 ± 1.2696 × 10(-7) mol/L, and for papaverine was 3.467 ± 1.2145 × 10(-6) mol/L. In segments pre-incubated with DETA-NONOate, the contractile response to phenylephrine was suppressed in the first 2 h post-incubation, compared with control responsive groups (p < 0.05), but this inhibition was revoked after 3 h post-incubation. We showed that DETA-NONOate has a more significant relaxative effect by comparison with papaverine; moreover, continuous and long-lasting nitric oxide production by DETA-NONOate might be of great importance for the outcome from coronary artery bypass grafting, when internal mammary artery is used as a conduit.
Nastaran Rahimi; Ahmad R Dehpour; Mehrak Javadi-Paydar; Hamid Sohanaki; Shahram Rabbani; Mohammad Ansari; Seyed Hossein Ahmadi Tafti
Related Documents :
12845997 - Treatment of portal vein septic thrombosis by infusion of antibiotics and an antifungal...
11702147 - Radio-frequency tissue ablation of the liver: effects of vascular occlusion on lesion d...
3500637 - Portal vein thrombosis following combined endoscopic variceal sclerosis and vasopressin...
21562357 - Transradial-occlusion-large-intercostal-branch-left-internal-mammary-artery-graft-novel...
18485757 - Successful treatment of a patient with a severely calcified aorta by an ascending aorta...
7773357 - A case of mesenteric venous thrombosis after endoscopic variceal band ligation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-25
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  -     ISSN:  1205-7541     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Tehran Heart Center, Tehran University of Medical Sciences, Tehran 1411713138, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effects of imagery training on fast isometric knee extensor torque development.
Next Document:  A new flavellagic acid derivative and phloroglucinol from Rhodomyrtus tomentosa.