Document Detail


Effect of D-penicillamine on lymphocyte function.
MedLine Citation:
PMID:  125594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lymphocyte stimulation by different stimulating agents was dose dependently inhibited by D-penicillamine (Metalcaptase-R). The influence of D-penicillamine on the lymphocyte metabolism after the stimulation was established, was time dependently reduced. After preincubation of lymphocytes with D-penicillamine the lymphocyte metabolism was dose dependently reduced. The inhibition of the mixed lymphocyte cultures was by far less extensive after preincubation of the stimulator cells than of the responder cells. HeLa-cells were dose dependently inhibited by D-penicillamine, too. From these results there is much to be said for the assumption that D-penicillamine acts at the level of the cell membrane. D-Penicillamine seems to affect "membrane dependent" metabolic processes rather than block antigenic or other immunologically relevant structures.
Authors:
K Schumacher; G Maerker-Alzer; R Preuss
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  25     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-11-07     Completed Date:  1975-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  603-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Membrane / drug effects
Hela Cells / drug effects,  immunology
Histocompatibility Antigens
Humans
Immunosuppression
Lectins / pharmacology
Lymphocyte Activation / drug effects*
Lymphocyte Culture Test, Mixed
Lymphocytes / drug effects*,  immunology
Middle Aged
Penicillamine / immunology,  pharmacology*
Tuberculin
Tuberculosis / immunology
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens; 0/Lectins; 0/Tuberculin; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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