| Effect of D-penicillamine on lymphocyte function. | |
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MedLine Citation:
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PMID: 125594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphocyte stimulation by different stimulating agents was dose dependently inhibited by D-penicillamine (Metalcaptase-R). The influence of D-penicillamine on the lymphocyte metabolism after the stimulation was established, was time dependently reduced. After preincubation of lymphocytes with D-penicillamine the lymphocyte metabolism was dose dependently reduced. The inhibition of the mixed lymphocyte cultures was by far less extensive after preincubation of the stimulator cells than of the responder cells. HeLa-cells were dose dependently inhibited by D-penicillamine, too. From these results there is much to be said for the assumption that D-penicillamine acts at the level of the cell membrane. D-Penicillamine seems to affect "membrane dependent" metabolic processes rather than block antigenic or other immunologically relevant structures. |
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Authors:
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K Schumacher; G Maerker-Alzer; R Preuss |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 25 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1975 Apr |
Date Detail:
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Created Date: 1975-11-07 Completed Date: 1975-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 603-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Membrane / drug effects Hela Cells / drug effects, immunology Histocompatibility Antigens Humans Immunosuppression Lectins / pharmacology Lymphocyte Activation / drug effects* Lymphocyte Culture Test, Mixed Lymphocytes / drug effects*, immunology Middle Aged Penicillamine / immunology, pharmacology* Tuberculin Tuberculosis / immunology |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens; 0/Lectins; 0/Tuberculin; 52-67-5/Penicillamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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