Document Detail


Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency.
MedLine Citation:
PMID:  21391259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder.
AIMS: To examine the influence of G72 variation on brain function in the healthy population.
METHOD: Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes.
RESULTS: G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05).
CONCLUSIONS: Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis.
Authors:
Diana P Prata; Sergio A Papagni; Andrea Mechelli; Cynthia H Y Fu; Joseph Kambeitz; Marco Picchioni; Fergus Kane; Sridevi Kalidindi; Colm McDonald; Eugenia Kravariti; Timothea Toulopoulou; Elvira Bramon; Muriel Walshe; Robin Murray; David A Collier; Philip K McGuire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-09
Journal Detail:
Title:  Human brain mapping     Volume:  33     ISSN:  1097-0193     ISO Abbreviation:  Hum Brain Mapp     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-15     Completed Date:  2012-04-10     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  9419065     Medline TA:  Hum Brain Mapp     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiology*
Brain Mapping
Carrier Proteins / genetics*
Female
Genotype
Glutamic Acid / metabolism*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net / physiology
Neuroimaging
Polymorphism, Single Nucleotide*
Verbal Behavior / physiology*
Grant Support
ID/Acronym/Agency:
G0300977//Medical Research Council; G0901310//Medical Research Council; PDA/02/06/016//Department of Health
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/DAOA protein, human; 3KX376GY7L/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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