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Effect of Acticoat® and Cutinova Hydro® on wound healing.
MedLine Citation:
PMID:  22682153     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, the effects of wound covering materials, Acticoat® and Cutinova Hydro® on wound healing have been studied in rabbit models with open and tissue-lost wounds with full-thickness flank excisions. Rabbits were used as subjects with three groups of four rabbits each, and trial periods of 7, 14 and 21 days. Four circular wounds of 1·5 cm diameter were made, two on right (one of them control) and two on left (one of them control) of the dorsal sides of abdomen. Acticoat® and Cutinova Hydro® were applied on the wounds with suture for a period of 21 days and one each placed on right and left sides as control with gauze. All biopsy specimens were taken from the animals at the end of the research periods to check the length of the epithelium, epithelial thickness, size of wounds, wound granulation tissue formation and histopathological evaluation for clarity. Acticoat® group showed better healing and scar formation compare to Cutinova Hydro® group by macroscopic examination. Epithelial wound length and clarity in terms of statistical difference occurred on day 21 (P < 0·05); while the length of the wound epithelium decreased patency, epithelial thickness on days 7, 14 and 21, showed no statistical differences (P > 0·05). As a result, the Acticoat® wound dressing was determined as more reliable for early wound healing. This study has shown the short-term clinical benefits of hydroactive, polyurethane dressings in the management of acute wounds. But, longer periods of wound healing procedure should be planned for reliable and safe results of wound dressing. It has also been concluded that microbiological analyses should also be included for more robust and reliable comparisons.
Authors:
Mustafa Arıcan; Fatih Hatipoglu; Aysen Uyaroglu; Ozgur Ozdemir; Kadircan Ozkan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-11
Journal Detail:
Title:  International wound journal     Volume:  -     ISSN:  1742-481X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. International Wound Journal © 2012 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Affiliation:
M Arıcan, BVSc, PhD, Department of Surgery, Faculty of Veterinary Science, The University of Selcuk, Konya, Turkey F Hatipoglu, BVSc, PhD, Department of Pathology, The University of Selcuk Faculty of Veterinary Science, Konya, Turkey A Uyaroglu, BVSc, PhD, Department of Surgery, Faculty of Veterinary Science, The University of Selcuk, Konya, Turkey O Ozdemir, BVSc, PhD, Department of Pathology, The University of Selcuk Faculty of Veterinary Science, Konya, Turkey K Ozkan, BVSc, PhD, Department of Surgery, Faculty of Veterinary Science, The University of Selcuk, Konya, Turkey.
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