Document Detail

Effect of Corynebacterium parvum on the class and subclass of antibody produced in the response of different strains of mice to sheep erythrocytes.
MedLine Citation:
PMID:  1092609     Owner:  NLM     Status:  MEDLINE    
Several strains of mice were injected with sheep erythrocytes (SRBC) using C. parvum as adjuvant. The adjuvant effects on the amounts of class and subclass of antibody produced were ranked in the order IgG2b greater than IgG2a and IgM greater than IgG1. In addition, these effects were shown to vary depending on the time of administration of C. parvum relative to antigen. C parvum was shown to have no adjuvant effect on the response of congenitally athymic mice when given at the same time as the antigen, SRBC. On the basis of the reported observations it is suggested that certain of the adjuvant effects of C. parvum require T-cell function.
G W Warr; K James
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Immunology     Volume:  28     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-08-07     Completed Date:  1975-08-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  431-42     Citation Subset:  IM    
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MeSH Terms
Adjuvants, Immunologic*
Antibody Formation*
Antibody-Producing Cells
Corynebacterium / immunology*
Erythrocytes / immunology*
Hemolytic Plaque Technique
Immunoglobulin G
Immunoglobulin M
Mice, Inbred Strains / immunology
Organ Size
Propionibacterium acnes / immunology*
Sheep / immunology
Spleen / immunology
Thymus Gland / immunology
Time Factors
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Immunoglobulin G; 0/Immunoglobulin M

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