| The Effect of a Contrast Agent on Proton Beam Range in Radiotherapy Planning Using Computed Tomography for Patients With Locoregionally Advanced Lung Cancer. | |
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MedLine Citation:
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PMID: 21497456 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: We evaluated the effect of a contrast agent (CA) on proton beam range in a treatment planning system (TPS) for patients with locoregionally advanced lung cancer. METHODS AND MATERIALS: Two sets of computed tomography (CT) images (with and without CA) were obtained from 20 patients with lung cancer. Because the increase in Hounsfield unit (∆HU) value of the heart and great vessels due to the effect of CA is most prominent among thoracic structures, to evaluate the effect of CA on proton beam range in the TPS, we compared the calculated distal ranges in the plan with CA-enhanced CT with those with corrected CT, in which the HU values of the heart and great vessels in the CA-enhanced CT were replaced by average HU values obtained from the unenhanced CT. RESULTS: The mean ∆HU value and the longest length of the heart and great vessels within the proton beam path in the field that passed through these structures were 189 ± 29 HU (range, 110-250 HU) and 7.1 ± 1.1 cm (range, 2.6-11.2 cm), respectively. The mean distal range error in the TPS because of the presence of CA was 1.0 ± 0.7 cm (range, 0.2-2.6 cm). CONCLUSION: If CA-enhanced CT images are used for radiotherapy planning using a proton beam for the treatment of lung cancer, our results suggest that the HU values of the heart and great vessels should be replaced by the average HU values of soft tissue to avoid discrepancies between planned and delivered doses. |
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Authors:
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Ui-Jung Hwang; Dong Ho Shin; Tae Hyun Kim; Sung Ho Moon; Young Kyung Lim; Hojin Jeong; Jeong-Eun Rah; Sang Soo Kim; Joo-Young Kim; Dae Yong Kim; Sung Yong Park; Kwan Ho Cho |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-14 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: - ISSN: 1879-355X ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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