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The Effect of a Connexin43-based peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial.
MedLine Citation:
PMID:  25072595     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The gap junction protein, connexin43 (Cx43) has critical roles in the inflammatory, edematous and fibrotic processes following dermal injury and during wound healing and is abnormally upregulated at the epidermal wound margins of venous leg ulcers. Targeting Cx43 with ACT1, a peptide mimetic of the carboxyl-terminus of Cx43, accelerates fibroblast migration and proliferation and accelerates wound reepitheliazation. In a prospective, multi-center clinical trial, conducted in India, Indian adults with chronic venous leg ulcers were randomized to treatment with an ACT1 gel formulation plus conventional standard of care protocols, involving maintaining wound moisture and four-layer compression bandage therapy, or standard of care protocols alone. The primary endpoint was mean percent ulcer reepitheliazation from baseline to 12 weeks. A significantly greater reduction in mean percent ulcer area from baseline to 12 weeks was associated with the incorporation of ACT1 therapy (79% (SD 50.4)) as compared to compression bandage therapy alone (36% (SD 179.8); P=0.02). Evaluation of secondary efficacy endpoints indicated a reduced median time to 50% and 100% ulcer epitheliazation for ACT1 treated ulcers. Incorporation of ACT1 in standard of care protocols may represent a well-tolerated, highly effective therapeutic strategy that expedites chronic venous ulcer healing by treating the underlying ulcer pathophysiology through Cx43 mediated pathways.Journal of Investigative Dermatology accepted article preview online, 29 July 2014; doi:10.1038/jid.2014.318.
Authors:
Gautam Ghatnekar; Christina Grek; David G Armstrong; Sanjay C Desai; Robert Gourdie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-29
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  -     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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