| Effect of combined treatment with curcumin and candesartan on ischemic brain damage in mice. | |
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MedLine Citation:
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PMID: 20719539 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The combined effects of curcumin and candesartan were investigated in brain ischemia induced by middle cerebral artery (MCA) occlusion (MCAO). Male mice were classified into 5 groups. The mice were killed 24 hours after MCAO, and each group was divided into 2 halves. In one half, brain homogenate was collected for antioxidant enzyme activity determination, and in the other half, samples were obtained for red color intensity determination in brain slices. The untreated group exhibited significantly reduced cerebral blood flow, increased lipid peroxide levels and heart rate, decreased superoxide dismutase (SOD) and glutathione-S-transferase (GST) activity, and reduced red color intensity compared with the sham group. Combination treatment with curcumin and candesartan significantly restored SOD and GST activity, thiobarbituric acid reactive substances, heart rate, blood flow, and red color intensity compared with the untreated group. The use of each drug alone significantly restored SOD and blood flow compared with the sham and untreated groups, heart rate decreased with curcumin alone, and red color intensity and nitric oxide level increased with candesartan alone. These results indicate that curcumin synergistically enhances the inhibitory action of candesartan on brain ischemia through suppression of blood flow changes and oxidative stress via antioxidant properties, suggesting beneficial combined effects of curcumin and candesartan on ischemic brain damage. |
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Authors:
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Azza S Awad |
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Publication Detail:
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Type: Journal Article Date: 2010-08-17 |
Journal Detail:
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Title: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Volume: 20 ISSN: 1532-8511 ISO Abbreviation: J Stroke Cerebrovasc Dis Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111633 Medline TA: J Stroke Cerebrovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 541-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pharmacology and Toxicology, Faculty Pharmacy, Al-Azhar University (Girls), Nasr City, Cairo, Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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