| Effect of Coenzyme Q(10) in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial. | |
| | |
MedLine Citation:
|
PMID: 20022408 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with a complex phenotype. Oxidative stress is known to play a major role in this pathology both due to genetic and epigenetic factors, suggesting that oxidative imbalance contributes to the clinical manifestation of DS. In particular, the implications of oxidative DNA damage in Down syndrome has been linked with neurodegeneration. Here we report the results of a double blind controlled trial aimed at investigating the protective effect of Coenzyme Q(10) on DNA oxidation in this clinical setting using the single cell gel electrophoresis technique. |
| | |
Authors:
|
L Tiano; P Carnevali; L Padella; L Santoro; F Principi; F Brugè; F Carle; R Gesuita; O Gabrielli; G P Littarru |
Related Documents
:
|
10484988 - Trisomy 21 as the sole abnormality in a refractory anemia with ring sideroblasts. 527248 - The dermatoglyphic pattern of the trisomy 9p syndrome. 8115398 - Segmental trisomy as a mouse model for down syndrome. 9401108 - A rare case of a liveborn with free, de novo and partial trisomy 12 and an unusual phen... 8275278 - Involvement of opioid mechanisms in the dorsal periaqueductal gray in drug abuse. 6654938 - Results of fasciotomy in patients with medial tibial syndrome or chronic anterior-compa... |
Publication Detail:
|
Type: Journal Article Date: 2009-12-21 |
Journal Detail:
|
Title: Neurobiology of aging Volume: 32 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-09-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
|
Languages: eng Pagination: 2103-5 Citation Subset: IM |
Copyright Information:
|
Copyright © 2009 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outbreak of late-onset group B Streptococcus in a neonatal intensive care unit.
Next Document: New pyrazoles incorporating pyrazolylpyrazole moiety: Synthesis, anti-HCV and antitumor activity.