Document Detail

Effect of Cochlear Window Fixation on Air- and Bone-Conduction Thresholds.
MedLine Citation:
PMID:  23150097     Owner:  NLM     Status:  Publisher    
HYPOTHESIS: In the absence of patent cochlear windows, cochlear fluid inertia depends on the presence of a "third window" as a major component of the bone-conduction response. BACKGROUND: Studies have shown conflicting results regarding changes in air and bone conduction whenever, the round window, oval window, or both windows were occluded. METHOD: The study was performed in a tertiary university-affiliated medical center. Auditory brain responses to clicks and 1-kHz tone bursts delivered by air and bone conduction were tested in 5 adult-size fat sand rats. The round window membrane (total, 7 ears) was sealed with Super Glue, and auditory brain response testing was repeated. Thereafter, the stapes footplate was firmly fixated, and auditory brain responses were recorded for a third time. RESULTS: Round-window fixation induced a significant increase in air-conduction thresholds to clicks from 36.4 ± 0.9 to 69.3 ± 4.1 dB SPL, with no significant change in bone-conduction thresholds. When the stapes footplate was immobilized as well, air conduction increased by another 20 dB, on average, with no change in bone conduction. A similar deterioration was seen in response to 1 kHz stimulus. CONCLUSION: These findings support and complement earlier studies in the same animal model, suggesting that when the pressure outlet through the cochlear windows are abolished, still bone conduction displaces the cochlear partition probably because of a functioning "third window."
Ben I Nageris; Joseph Attias; Rafi Shemesh; Roy Hod; Michal Preis
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Publication Detail:
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  33     ISSN:  1537-4505     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1679-1684     Citation Subset:  -    
*Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petach Tikva; †Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; ‡Department of Communication Sciences and Disorders, University of Haifa, Haifa; and §Institute for Audiology and Clinical Neurophysiology, Schneider Children's Medical Center of Israel, Petach Tikva; Israel.
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