| Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo. | |
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MedLine Citation:
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PMID: 19153985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Citrus paradisi (grapefruit) consumption is considered as beneficial and it is popularly used for the treatment of a vast array of diseases, including hypertension. In the present study, the coronary vasodilator and hypotensive effects of Citrus paradisi peel extract were assessed in the Langendorff isolated and perfused heart model and in the heart and lung dog preparation. In both models, Citrus paradisi peel extract decreased coronary vascular resistance and mean arterial pressure when compared with control values (60 +/- 15 x 10(7) dyn s cm(-5) vs 100 +/- 10 x 10(7) dyn s cm(-5) and 90 mmHg vs 130 +/- 15 mmHg, respectively). These decreases in coronary vascular resistance and mean arterial pressure were blocked when isolated and perfused hearts and mongrel dogs were pre-treated with L-NAME. In humans, Citrus paradisi juice decreased diastolic arterial pressure and systolic arterial pressure both in normotensive and hypertensive subjects. Citrus paradisi juice produced a greater decrease in mean arterial pressure when compared with Citrus sinensis juice, cow milk and a vitamin C-supplemented beverage. However, more detailed studies are required to isolate, purify and evaluate the chemical compounds responsible for this pharmacological effect and to clarify its possible role for treating hypertension. |
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Authors:
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J A Díaz-Juárez; F A Tenorio-López; G Zarco-Olvera; L Del Valle-Mondragón; J C Torres-Narváez; G Pastelín-Hernández |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 23 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-25 Completed Date: 2009-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 948-54 Citation Subset: IM |
Copyright Information:
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Copyright 2009 John Wiley & Sons, Ltd. |
Affiliation:
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Departamento de Farmacología, Instituto Nacional de Cardiología 'Ignacio Chávez', Juan Badiano No. 1, Sección XVI, 14080, Tlalpan, México D.F., México. JulietaAnabell@terra.com.mx |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology* Blood Pressure / drug effects* Citrus paradisi / chemistry Dogs Female Heart / drug effects* Humans Hypertension / drug therapy Lung / drug effects Male NG-Nitroarginine Methyl Ester / pharmacology Plant Extracts / pharmacology* Rats Rats, Wistar Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Plant Extracts; 50903-99-6/NG-Nitroarginine Methyl Ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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