Document Detail

Effect of cibenzoline on biventricular pressure gradients in a pediatric patient with hypertrophic obstructive cardiomyopathy.
MedLine Citation:
PMID:  20140606     Owner:  NLM     Status:  MEDLINE    
This report presents the case of an 8-year-old male with biventricular hypertrophic obstructive cardiomyopathy who achieved a successful reduction of the pressure gradients by treatment with cibenzoline. Ultrasound echocardiography showed marked intraventricular septal hypertrophy and left midventricular and right ventricular outflow obstructions. A cardiac catheterization revealed left midventricular and right outflow obstructions associated with pressure gradients of 100 and 35 mmHg, respectively. An intravenous injection of 28 mg (1.4 mg/kg) cibenzoline immediately improved the biventricular pressure gradients. Therefore, oral cibenzoline treatment was initiated, the dose was increased to 150 mg/day, and both pressure gradients remained low, without any complications at the time of discharge, 4 months later.
Takamichi Ishikawa; Satoru Iwashima; Takehiko Ohzeki
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-02-07
Journal Detail:
Title:  Pediatric cardiology     Volume:  31     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-17     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  707-10     Citation Subset:  IM    
Department of Pediatrics, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Japan.
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MeSH Terms
Anti-Arrhythmia Agents / administration & dosage,  therapeutic use*
Cardiomyopathy, Hypertrophic / drug therapy*,  physiopathology,  ultrasonography
Heart Catheterization
Imidazoles / administration & dosage,  therapeutic use*
Ventricular Outflow Obstruction / drug therapy*,  physiopathology,  ultrasonography
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Imidazoles; 53267-01-9/cifenline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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