| Effect of chronic sildenafil treatment on penile endothelial function: a randomized, double-blind, placebo controlled study. | |
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MedLine Citation:
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PMID: 19837434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Although the effect of phosphodiesterase type 5 inhibitors on endothelial function in the systemic circulation has been extensively studied, its effect on penile endothelial function remains unexplored. Therefore, we evaluated the effect of daily sildenafil on penile endothelial function. MATERIALS AND METHODS: A total of 60 patients with erectile dysfunction were randomized blindly to daily placebo or 50 mg sildenafil for 4 weeks. Penile and forearm blood flow as well as endothelial function indices were measured at baseline and after 4 weeks using venoocclusive strain gauge plethysmography for both organs. Sequential changes in flow, maximal blood flow and area under the curve induced by reactive hyperemia after 5 minutes of transient ischemia were considered indices of endothelial function. RESULTS: There were 34 patients treated with sildenafil and 19 on placebo who completed the study. The general characteristics of both groups were comparable. Mean +/- SEM baseline penile blood flow was 6.2 +/- 1.4 and 7.0 +/- 0.6 ml/dl per minute for the placebo and sildenafil groups, respectively (p = 0.54). Baseline forearm blood flow was similar in both groups. At baseline penile AUC was 420 +/- 50 and 520 +/- 50 (p = 0.18), and in the forearm it was 445 +/- 40 and 410 +/- 40 (p = 0.45) for the placebo and sildenafil groups, respectively. After 4 weeks on the assigned drug penile blood flow increased to 11.2 +/- 2 ml/dl per minute in the sildenafil group (p = 0.02) and remained unchanged in the placebo group. After 4 weeks penile AUC increased to 720 +/- 65 in the sildenafil group (0.04) and remained unchanged in the placebo group. Placebo and sildenafil did not affect the indices of forearm endothelial function. CONCLUSIONS: Daily sildenafil significantly improves penile blood flow and penile endothelial function indices without causing any relevant systemic effects. |
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Authors:
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Yoram Vardi; Boaz Appel; Yaron Ofer; Ilan Greunwald; Lior Dayan; Giris Jacob |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-10-17 |
Journal Detail:
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Title: The Journal of urology Volume: 182 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 2850-5 Citation Subset: AIM; IM |
Affiliation:
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Neurourology Unit, Rambam Medical Center and Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. yvardi@rambam.health.gov.il |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00297544 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Double-Blind Method Endothelium, Vascular / drug effects*, physiology* Erectile Dysfunction / drug therapy* Humans Male Middle Aged Penis / blood supply* Phosphodiesterase Inhibitors / administration & dosage, pharmacology* Piperazines / administration & dosage, pharmacology* Purines / administration & dosage, pharmacology Sulfones / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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