| Effect of chorda tympani nerve transection on salt taste perception in mice. | |
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MedLine Citation:
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PMID: 21743094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of gustatory nerve transection on salt taste have been studied extensively in rats and hamsters but have not been well explored in the mouse. We examined the effects of chorda tympani (CT) nerve transection on NaCl taste preferences and thresholds in outbred CD-1 mice using a high-throughput phenotyping method developed in our laboratory. To measure taste thresholds, mice were conditioned by oral self-administration of LiCl or NaCl and then presented with NaCl concentration series in 2-bottle preference tests. LiCl-conditioned and control NaCl-exposed mice were given bilateral transections of the CT nerve (LiCl-CTX, NaCl-CTX) or were left intact as controls (LiCl-CNT, NaCl-CNT). After recovery from surgery, mice received a concentration series of NaCl (0-300 mM) in 48-h 2-bottle tests. CT transection increased NaCl taste thresholds in LiCl-conditioned mice and eliminated avoidance of concentrated NaCl in control NaCl-exposed mice. This demonstrates that in mice, the CT nerve is important for detection and recognition of NaCl taste and is necessary for the normal avoidance of high concentrations of NaCl. The results of this experiment also show that the method of high-throughput phenotyping of salt taste thresholds is suitable for detecting changes in the taste periphery in mouse genetic studies. |
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Authors:
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Glen J Golden; Yutaka Ishiwatari; Maria L Theodorides; Alexander A Bachmanov |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-07-09 |
Journal Detail:
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Title: Chemical senses Volume: 36 ISSN: 1464-3553 ISO Abbreviation: Chem. Senses Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-18 Completed Date: 2012-02-14 Revised Date: 2013-03-11 |
Medline Journal Info:
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Nlm Unique ID: 8217190 Medline TA: Chem Senses Country: England |
Other Details:
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Languages: eng Pagination: 811-9 Citation Subset: IM |
Affiliation:
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Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA. ggolden@monell.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chorda Tympani Nerve / injuries, physiology* Male Mice Sodium Chloride, Dietary / metabolism* Taste Perception* / physiology |
| Grant Support | |
ID/Acronym/Agency:
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5T32DC000014-30/DC/NIDCD NIH HHS; R01 DC000882/DC/NIDCD NIH HHS; R01 DC00882/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium Chloride, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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