Document Detail

Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis.
MedLine Citation:
PMID:  16802773     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Jia Wei Cang Er Zi San, a traditional Chinese herbal formula, has been used to treat allergic rhinitis (AR) for several centuries. However, its effect on experimental animal models and its therapeutic mechanism remain unclear.
OBJECTIVE: To study the effect of Shu-Bi-Lin, a modified Jia Wei Cang Er Zi San, on an animal model of AR.
METHODS: Shu-Bi-Lin was administered to the guinea pig model of AR. Meanwhile, an antihistamine-treated group for the treatment control, an ovalbumin-sensitized and untreated group for the positive control, and a sham-sensitized, sham-challenged group for the sham control were studied in parallel. Symptomatic and some pathophysiologic variables were evaluated.
RESULTS: Sneezing and nasal scratching after challenges were significantly ameliorated in the Shu-Bi-Lin-treated group compared with the ovalbumin-sensitized and untreated group, but rhinorrhea volume was not reduced. Shu-Bi-Lin significantly suppressed the production of IgG1 in the passive cutaneous anaphylaxis test. The thromboxane B2 level in nasal lavage fluid was significantly deceased in the Shu-Bi-Lin-treated group; however, the reduction in histamine and peptide leukotriene levels did not reach statistical significance. In addition, eosinophil infiltration and endothelial nitric oxide synthase immunoreactivity in the nasal tissues were reduced in the Shu-Bi-Lin-treated group.
CONCLUSIONS: Shu-Bi-Lin could alleviate the nasal symptoms of AR, and its mechanism might be related to its inhibitory effect on type I anaphylaxis reactions and eosinophil infiltration in the nasal tissues, as well as the inhibition of some mediators related to AR.
Yu Zhao; Charlie A van Hasselt; John K Woo; George G Chen; Yeuk O Wong; Li H Wang; Ping C Leung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  96     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-28     Completed Date:  2006-07-18     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-50     Citation Subset:  IM    
Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
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MeSH Terms
Anti-Allergic Agents / pharmacology*
Disease Models, Animal
Drugs, Chinese Herbal / pharmacology*
Eosinophils / drug effects,  immunology
Guinea Pigs
Histamine / analysis
Histamine H1 Antagonists, Non-Sedating / pharmacology
Immunoglobulin E / blood
Immunoglobulin G / blood
Leukotrienes / analysis
Loratadine / analogs & derivatives,  pharmacology
Nasal Lavage Fluid / chemistry
Nasal Mucosa / drug effects,  immunology,  pathology
Nitric Oxide Synthase Type II / metabolism
Nitric Oxide Synthase Type III / metabolism
Ovalbumin / pharmacology
Rhinitis / blood,  drug therapy*,  immunology
Sneezing / drug effects
Thromboxane B2 / analysis
Reg. No./Substance:
0/Anti-Allergic Agents; 0/Drugs, Chinese Herbal; 0/Histamine H1 Antagonists, Non-Sedating; 0/Immunoglobulin G; 0/Leukotrienes; 0/Shi-Bi-Lin herbal formula; 37341-29-0/Immunoglobulin E; 51-45-6/Histamine; 54397-85-2/Thromboxane B2; 79794-75-5/Loratadine; 9006-59-1/Ovalbumin; EC Oxide Synthase Type II; EC Oxide Synthase Type III; FVF865388R/desloratadine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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