| Effect of Cerebral Amyloid Angiopathy on Brain Iron, Copper, and Zinc in Alzheimer's Disease. | |
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MedLine Citation:
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PMID: 21187585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cerebral amyloid angiopathy (CAA) is a vascular lesion associated with Alzheimer's disease (AD) present in up to 95% of AD patients and produces MRI-detectable microbleeds in many of these patients. It is possible that CAA-related microbleeding is a source of pathological iron in the AD brain. Because the homeostasis of copper, iron, and zinc are so intimately linked, we determined whether CAA contributes to changes in the brain levels of these metals. We obtained brain tissue from AD patients with severe CAA to compare to AD patients without evidence of vascular amyloid-β. Patients with severe CAA had significantly higher non-heme iron levels. Histologically, iron was deposited in the walls of large CAA-affected vessels. Zinc levels were significantly elevated in grey matter in both the CAA and non-CAA AD tissue, but no vascular staining was noted in CAA cases. Copper levels were decreased in both CAA and non-CAA AD tissues and copper was found to be prominently deposited on the vasculature in CAA. Together, these findings demonstrate that CAA is a significant variable affecting transition metals in AD. |
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Authors:
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Matthew Schrag; Andrew Crofton; Matthew Zabel; Arshad Jiffry; David Kirsch; April Dickson; Xiao Wen Mao; Harry V Vinters; Dylan W Domaille; Christopher J Chang; Wolff Kirsch |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-27 |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: - ISSN: 1875-8908 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, California, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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