Document Detail


Effect of cell geometry on conduction velocity in a subcellular model of myocardium.
MedLine Citation:
PMID:  20501344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied the effect of cell geometry on propagation velocity of the cardiac impulse using a subcellular computer model of myocardium. Variation of cell size has only small effects on longitudinal and transverse conduction velocities, when the ratio of cell length/width is constant, for cell sizes (length x width) between (60 microm x 20 microm) and (120 microm x 40 microm). The results were not dependent on gap-junction conductance (range 0.25-1 microS), gap-junction distribution, or the specific tissue architecture. Longitudinal conduction velocity increased with the cell length/width ratio and transverse velocity decreased. The cell length/width ratio was a good estimator of the anisotropic ratio. In conclusion, cell length/width ratio is more important than cell size in determining conduction velocity.
Authors:
Amadou Toure; Candido Cabo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-24
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  57     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2107-14     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, City College of New York, City University of New York, New York, NY 10031, USA. amadou@ees1s0.engr.ccny.cuny.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anisotropy
Cell Shape / physiology*
Cell Size
Cells, Cultured
Computer Simulation
Dogs
Electric Conductivity
Electrophysiological Phenomena
Gap Junctions / physiology
Heart Conduction System / physiology*
Models, Cardiovascular*
Myocardium / cytology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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