Document Detail

Effect of cataract in evaluation of macular pigment optical density by autofluorescence spectrometry.
MedLine Citation:
PMID:  21071730     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients.
METHODS: MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline.
RESULTS: Forty-five eyes of 41 subjects, who had no ocular disorders or fundus autofluorescence abnormalities except for age-related nuclear cataract, were included. Preoperative MPOD was 0.350 ± 0.117 density unit (DU). Regression analysis showed that a higher nuclear color score correlated with lower MPOD (t = -2.90, P = 0.0063). The preoperative MPOD prediction formula was MPOD = 0.545 - 0.069 × nuclear color score. A higher nuclear color score correlated significantly with failure to measure the MPOD (χ(2) = 5.08, P = 0.0242). The mean postoperative MPOD was 0.600 DU (95% confidence interval [CI], 0.562-0.637), which was significantly (P < 0.0001) higher than the preoperative level of 0.350 DU (95% CI, 0.313-0.388). Regression analysis showed that higher preoperative MPOD correlated with higher postoperative MPOD (t = 2.91, P = 0.0061).
CONCLUSIONS: Cataract, especially its nuclear component, affects MPOD measured by autofluorescence spectrometry. Care should be taken when using this method in eyes with age-related macular maculopathy and age-related macular degeneration and in older patients who may develop these diseases.
Yuzuru Sasamoto; Fumi Gomi; Miki Sawa; Hirokazu Sakaguchi; Motokazu Tsujikawa; Kohji Nishida
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-16
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-04-01     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  927-32     Citation Subset:  IM    
Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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MeSH Terms
Cataract / metabolism*
Lens Implantation, Intraocular
Lutein / metabolism*
Macula Lutea / metabolism*
Prospective Studies
Retinal Pigments / metabolism*
Spectrometry, Fluorescence
Xanthophylls / metabolism*
beta Carotene / metabolism
Reg. No./Substance:
0/Retinal Pigments; 0/Xanthophylls; 127-40-2/Lutein; 144-68-3/zeaxanthin; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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