| Effect of cataract in evaluation of macular pigment optical density by autofluorescence spectrometry. | |
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MedLine Citation:
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PMID: 21071730 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To assess the effect of cataract on the evaluation of macular pigment optical density (MPOD) in aged patients. METHODS: MPOD was prospectively measured using autofluorescence spectrometry before and after cataract surgery. The Lens Opacities Classification System III was used to grade the cataracts at baseline. RESULTS: Forty-five eyes of 41 subjects, who had no ocular disorders or fundus autofluorescence abnormalities except for age-related nuclear cataract, were included. Preoperative MPOD was 0.350 ± 0.117 density unit (DU). Regression analysis showed that a higher nuclear color score correlated with lower MPOD (t = -2.90, P = 0.0063). The preoperative MPOD prediction formula was MPOD = 0.545 - 0.069 × nuclear color score. A higher nuclear color score correlated significantly with failure to measure the MPOD (χ(2) = 5.08, P = 0.0242). The mean postoperative MPOD was 0.600 DU (95% confidence interval [CI], 0.562-0.637), which was significantly (P < 0.0001) higher than the preoperative level of 0.350 DU (95% CI, 0.313-0.388). Regression analysis showed that higher preoperative MPOD correlated with higher postoperative MPOD (t = 2.91, P = 0.0061). CONCLUSIONS: Cataract, especially its nuclear component, affects MPOD measured by autofluorescence spectrometry. Care should be taken when using this method in eyes with age-related macular maculopathy and age-related macular degeneration and in older patients who may develop these diseases. |
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Authors:
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Yuzuru Sasamoto; Fumi Gomi; Miki Sawa; Hirokazu Sakaguchi; Motokazu Tsujikawa; Kohji Nishida |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-02-16 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-04-01 Revised Date: 2013-01-09 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 927-32 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aging Cataract / metabolism* Female Humans Lens Implantation, Intraocular Lutein / metabolism* Macula Lutea / metabolism* Male Phacoemulsification* Prospective Studies Retinal Pigments / metabolism* Spectrometry, Fluorescence Xanthophylls / metabolism* beta Carotene / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Retinal Pigments; 0/Xanthophylls; 127-40-2/Lutein; 144-68-3/zeaxanthin; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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