| Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats. | |
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MedLine Citation:
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PMID: 12693765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM OF THE STUDY: The main aim was to demonstrate the effects of Cassia auriculata flowers on blood glucose and lipid levels in experimental diabetic rats. METHODOLOGY: Aqueous extract of Cassia auriculata flowers was administered orally and different doses of the extract on blood glucose, haemoglobin, glycosylated haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug. RESULTS: Cassia auriculata flower extract (CFEt), at doses of 0.15, 0.30 and 0.45 g/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Cassia auriculata at 0.45 g/kg was found to be comparable to glibenclamide. CONCLUSION: Our findings indicate that the Cassia auriculata flowers possess antihyperlipidaemic effect in addition to antidiabetic activity. |
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Authors:
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L Pari; M Latha |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Singapore medical journal Volume: 43 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-04-15 Completed Date: 2003-06-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: Singapore |
Other Details:
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Languages: eng Pagination: 617-21 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Science Annamalai University, Annamalai Nagar Tamil Nadu-608 002, India. Paribala@sancharnet.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / pharmacology* Blood Glucose / metabolism* Cassia* Diabetes Mellitus, Experimental / blood, drug therapy* Dose-Response Relationship, Drug Flowers Glyburide / administration & dosage Hypoglycemic Agents / pharmacology* Lipids / blood* Male Phytotherapy* Rats Rats, Wistar Tissue Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Blood Glucose; 0/Hypoglycemic Agents; 0/Lipids; 0/Tissue Extracts; 10238-21-8/Glyburide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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