Document Detail


Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats.
MedLine Citation:
PMID:  12693765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM OF THE STUDY: The main aim was to demonstrate the effects of Cassia auriculata flowers on blood glucose and lipid levels in experimental diabetic rats. METHODOLOGY: Aqueous extract of Cassia auriculata flowers was administered orally and different doses of the extract on blood glucose, haemoglobin, glycosylated haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug. RESULTS: Cassia auriculata flower extract (CFEt), at doses of 0.15, 0.30 and 0.45 g/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Cassia auriculata at 0.45 g/kg was found to be comparable to glibenclamide. CONCLUSION: Our findings indicate that the Cassia auriculata flowers possess antihyperlipidaemic effect in addition to antidiabetic activity.
Authors:
L Pari; M Latha
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Singapore medical journal     Volume:  43     ISSN:  0037-5675     ISO Abbreviation:  Singapore Med J     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-04-15     Completed Date:  2003-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404516     Medline TA:  Singapore Med J     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  617-21     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Science Annamalai University, Annamalai Nagar Tamil Nadu-608 002, India. Paribala@sancharnet.in
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MeSH Terms
Descriptor/Qualifier:
Animals
Antilipemic Agents / pharmacology*
Blood Glucose / metabolism*
Cassia*
Diabetes Mellitus, Experimental / blood,  drug therapy*
Dose-Response Relationship, Drug
Flowers
Glyburide / administration & dosage
Hypoglycemic Agents / pharmacology*
Lipids / blood*
Male
Phytotherapy*
Rats
Rats, Wistar
Tissue Extracts / pharmacology*
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Blood Glucose; 0/Hypoglycemic Agents; 0/Lipids; 0/Tissue Extracts; 10238-21-8/Glyburide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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