| Effect of Carvedilol Versus Metoprolol CR/XL on Mortality in Patients With Heart Failure Treated With Cardiac Resynchronization Therapy: A COX Multivariate Regression Analysis. | |
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MedLine Citation:
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PMID: 21642836 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We investigated in 136 consecutive patients with heart failure receiving cardiac resynchronization therapy (CRT) the effect of carvedilol versus metoprolol CR/XL versus no beta blocker on mortality. Of the 136 patients, 42 (31%) were on carvedilol, 80 (59%) were on metoprolol CR/XL, and 14 (10%) were not on a beta blocker. A decrease of left ventricular end-systolic volume ≥15% after CRT was defined as a positive response to CRT. Of the 136 patients, 62 (46%) responded to CRT. It was found that both carvedilol and metoprolol CR/XL were not related to CRT response on using Cox univariate regression analysis. Twenty-two of the 136 patients (16%) died during follow-up of 17 ± 10 months after initiating CRT. Mortality occurred in 14 of 80 patients (18%) on metoprolol CR/XL, in 3 of 42 patients (7%) on carvedilol, and in 5 of 14 patients (36%) not on beta blockers (P = 0.04). After adjustment for age, gender, and the variables with significant differences by Cox univariate regression, both carvedilol (hazard ratio = 0.14; P = 0.03; 95% confidence interval = 0.02-0.86) and metoprolol CR/XL (hazard ratio = 0.19; P = 0.02; 95% confidence interval = 0.04-0.80) were found to be related to mortality by Cox multivariate regression. |
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Authors:
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Xuedong Shen; Chandra K Nair; Wilbert S Aronow; Tom Hee; Dennis J Esterbrooks |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-03 |
Journal Detail:
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Title: American journal of therapeutics Volume: - ISSN: 1536-3686 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441347 Medline TA: Am J Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Cardiac Center of Creighton University School of Medicine, Omaha, NE; and 2Cardiology Division, Department of Medicine, New York Medical College, Valhalla, NY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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