| Effect of Carvedilol and Nebivolol on Oxidative Stress-related Parameters and Endothelial Function in Patients with Essential Hypertension. | |
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MedLine Citation:
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PMID: 22703478 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Oxidative stress and endothelial dysfunction have been associated with essential hypertension (EH) mechanisms. The purpose of this study was to evaluate the effect of carvedilol and nebivolol on the oxidative stress-related parameters and endothelial function in patients with essential hypertension. The studied population included 57 patients, either sex, between 30 and 75 years of age, with mild to moderate EH complications. Participants were randomized to receive either carvedilol (12.5 mg) (n=23) or nebivolol (5 mg) (n=21) for 12 weeks. Measurements included; 24-hr ambulatory blood pressure (BP), flow-mediated dilatation (FMD), levels of NO estimated as nitrite - a NO metabolite (NO(2) ) - in plasma, and oxidative stress-related parameters in plasma and erythrocyte. EH patients who were treated with nebivolol or carvedilol showed systolic BP reductions of 17.4 mmHg and 19.9 mmHg, respectively, compared to baseline values (p <0.01). Diastolic BP was reduced by 13.7 mmHg and 12.8 mmHg after the treatment with nebivolol and carvedilol, respectively (p <0.01) (fig. 2B). Nebivolol and carvedilol showed 7.3 and 8.1% higher endothelium-dependent dilatation in relation to baseline values (p <0.05). FRAP and GSH/GSSH ratio showed 31.5 and 29.6% higher levels in the carvedilol group compared with basal values; however, nebivolol-treated patients did not show significant differences after treatment. On the other hand, the NO(2) plasma concentration was not modified by the administration of carvedilol. However, nebivolol enhanced these levels in 62.1% after the treatment. In conclusion, this study demonstrated the antihypertensive effect of both beta-blockers. However, carvedilol could mediate these effects by an increase in antioxidant capacity and nebivolol through the raise in NO(2) concentration. Further studies are needed to determine the molecular mechanism of these effects. |
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Authors:
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Ramiro J Zepeda; Rodrigo Castillo; Ramón Rodrigo; Juan Carlos Prieto; Ivonne Aramburu; Solange Brugere; Katia Galdames; Viviana Noriega; Hugo F Miranda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-16 |
Journal Detail:
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Title: Basic & clinical pharmacology & toxicology Volume: - ISSN: 1742-7843 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208422 Medline TA: Basic Clin Pharmacol Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society. |
Affiliation:
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Molecular and Clinical Pharmacology Program, Biomedical Sciences Institute, Faculty of Medicine, Universidad de Chile. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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