Document Detail


Effect of Cardiopulmonary Resuscitation on Restoration of Myocardial ATP in Prolonged Ventricular Fibrillation.
MedLine Citation:
PMID:  22727945     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: There has been controversy over whether a short period of cardiopulmonary resuscitation (CPR) prior to defibrillation improves survival in patients who experienced a sudden cardiac arrest. However, there have been no reports about whether CPR restores the myocardial energy source during prolonged ventricular fibrillation (VF). The aim of this study is to investigate the effect of CPR in restoring myocardial high energy phosphates during prolonged VF. METHODS AND RESULTS: Seventy-two adult male Sprague-Dawley rats were used in this study. Baseline adenosine triphosphate (ATP) and adenosine diphosphate (ADP) prior to induction of VF were measured in nine rats, the No-VF group. Sixty-three rats were subjected to four minutes of untreated VF. Animals were then randomized into two groups: No-CPR (n=37) and CPR (n=26). In the No-CPR group, ATPs and ADPs were measured at four (No-CPR4), six (No-CPR6), eight (No-CPR8) or ten (No-CPR10) minutes after the induction of VF. The CPR group received two (CPR2), four (CPR4) or six (CPR6) minutes of mechanical chest compressions before ATP was measured. Myocardial ATP (nmol/mg protein) was decreased as VF duration was prolonged (No-VF: 5.49±1.71, No-CPR4: 4.27±1.58, No-CPR6: 4.13±1.31, No-CPR8: 3.77±1.42, No-CPR10: 3.52±0.90, p<0.05 between each of No-CPRs vs. No-VF). Two minutes of CPR restored myocardial ATP to the level of No-VF group (5.27±1.67 nmol/mg protein in CPR2, p>0.05 vs. No-VF group). However, myocardial ATP (nmol/mg protein) decreased if the duration of CPR was longer than two minutes (CPR4: 3.77±1.05, CPR6: 3.49±1.08, p<0.05 between CPR4 and CPR6 vs. No-VF). CONCLUSIONS: CPR for two minutes helps to maintain myocardial ATP after prolonged VF.
Authors:
Han Joo Choi; Tuyet Nguyen; Kyu Sang Park; Kyung Chul Cha; Hyun Kim; Kang Hyun Lee; Sung Oh Hwang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Resuscitation     Volume:  -     ISSN:  1873-1570     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Emergency Medicine, College of Medicine, Dankook University, Cheonan, Republic of Korea.
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