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Effect of Carbamazepine Therapy on Homocysteine, Vitamin B12, Folic Acid Levels in Children with Partial Epilepsy.
MedLine Citation:
PMID:  23255689     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To compare level of homocysteine, vitamin B12 and folic acid before and after 6 months of carbamazepine therapy and to correlate them with carbamazepine level at 6 months. DESIGN- Prospective comparative study. SETTING-Tertiary care centre in North India. PARTICIPANTS- 51 children (2-12 years of age) presenting with motor partial seizures. INTERVENTION- Carbamazepine therapy for six months. MAIN OUTCOME MEASURE- Change in homocysteine, B12, folic acid level. Methods-Children received carbamazepine in a dose of 10-20mg/kg/day. Fasting venous samples were collected before carbamazepine therapy and after six months. Homocysteine was analysed using homocysteine enzyme immunoassay. Vitamin B12 and folic acid were estimated using electrochemiluminesence technique. Carbamazepine levels were measured at 6 months. RESULTS: Of the 51 children, 36(males-21, females-15) were followed up and their data analyzed. Mean homocysteine level was 11.51±3.95 umol/l at recruitment and 11.77±6.65 umol/l at six months (p=0.785). At recruitment 6(16%) children had homocysteine level above 15 umol/L which increased to 10(27.77%) at 6 months. Mean vitamin B12 at recruitment was 292.1±111.2pg/ml and 297.8±82.9 pg/ml at 6 months (p=0.764). Mean folic acid at recruitment was 9.98±3.45 ng/ml and 10.66±3.97 ng/ml at 6 months (p=0.358). There was no correlation between carbamazepine levels with homocysteine, vitamin B12 and folic acid (p>;0.05).Most common finding on neuroimaging was neurocysticercosis (90.6%). There was no correlation between carbamazepine levels or dose at 6 months with homocysteine, vitamin B12 and folic acid levels (p>;0.05).There was no effect of age, sex or dietary pattern on homocysteine levels(P>;0.05). Most common finding on neuroimaging was neurocysticercosis (90.6%). CONCLUSION: Hence 6 months of carbamazepine therapy did not cause significant change in homocysteine, vitamin B12 and folic acid levels.
Authors:
Vimal Kumar; Anju Aggarwal; Sangeeta Sharma; Neelam Chillar; Hema Mittal; M Ma Faridi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-05
Journal Detail:
Title:  Indian pediatrics     Volume:  -     ISSN:  0974-7559     ISO Abbreviation:  Indian Pediatr     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, University College of Medical Sciences (University of Delhi)and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, Department of Neuropshycopharmacology*, Institute of Human Behaviour and Allied Sciences, New Delhi, Department of Neurochemistry**, Institute of Human Behaviour and Allied Sciences, New Delhi, India. Correspondence to: Dr Anju Aggarwal, Flat No. 3C, Block C2B, Janakpuri, New Delhi 110 058, India. aanju67@gmail.com.
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