| Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats. | |
MedLine Citation:
|
PMID: 20729756 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The effects of calcitonin gene-related peptide (CGRP) receptor antagonism with CGRP 8-37 on blood pressure changes evoked by the intravenous administration of the vasoactive modulators angiotensin II, phenylephrine, adenosine, nitroglycerine, and sodium nitroprusside were assessed in conscious rats. The effects of sumatriptan and dihydroergotamine on the blood pressure responses evoked by these vasomodulators also were assessed. The intravenous test dose of CGRP 8-37 was validated through block of depressor responses to intravenous CGRP in conscious rats, whereas the intravenous test doses of sumatriptan and dihydroergotamine were validated by reductions in carotid blood flow in anesthetized rats. CGRP 8-37 had no significant effects on blood pressure dose-response profiles and individual dose blood pressure responses to any of the vasomodulators tested. In contrast, sumatriptan altered the blood pressure dose-response profiles to angiotensin II and sodium nitroprusside (P < 0.03) and dihydroergotamine altered the blood pressure dose-response profile to sodium nitroprusside (P < 0.02) and tended to alter that of phenylephrine (P = 0.06). Both sumatriptan and dihydroergotamine displayed frequent alterations of individual dose blood pressure responses to all vasomodulators. These findings are consistent with concerns for sumatriptan and dihydroergotamine to alter systemic hemodynamics, whereas CGRP receptor antagonism did not display the same hemodynamic liability. |
Authors:
|
Joseph J Lynch; Theodore J Detwiler; Stefanie A Kane; Christopher P Regan |
Related Documents
:
|
25324866 - Correlation between the morning hypertension on ambulatory blood pressure monitoring an... 2628496 - Unclipping of two-kidney, one clip hypertensive rats produces endothelium-dependent inh... 9843886 - Effect of ovariectomy in heart failure-prone shhf/mcc-facp rats. 6688586 - Blood pressure and heart rate effect of a vasopressin antagonist in conscious normotens... 20105046 - The effect of body fat, aging, and diabetes on vertical and shear pressure in and under... 16547426 - New concepts of the management of one-lung ventilation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 56 ISSN: 1533-4023 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 518-25 Citation Subset: IM |
Affiliation:
|
Department of Central Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA. joseph_lynch@merck.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Therapeutic Advances in MicroRNA Targeting.
Next Document: Endothelium-dependent cerebral artery dilation mediated by transient receptor potential and Ca2+-act...