Document Detail

Effect of CaF2 on densification and properties of hydroxyapatite-zirconia composites for biomedical applications.
MedLine Citation:
PMID:  12182313     Owner:  NLM     Status:  MEDLINE    
Hydroxyapatite (HA) composites with zirconia (ZrO2) up to 40 vol% were fabricated with the addition of CaF2. The sinterability of the composites was found to be enhanced markedly by the addition of small amounts of CaF2 (< 5 vol%). Decomposition of HA to beta-TCP was suppressed due to the substitution of F- for OH-, consequently forming fluor-hydroxyapatite (FHA) solid solution. This suppression of decomposition allowed the production of a fully dense body, which retained both high flexural strength and fracture toughness. The osteoblast-like cell (MG63) response to these F- ion-containing composites displayed comparable cell viability to pure-HA by in vitro proliferation test.
Hae-Won Kim; Yoon-Jung Noh; Young-Hag Koh; Hyoun-Ee Kim; Hyun-Man Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  23     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-08-16     Completed Date:  2003-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  4113-21     Citation Subset:  IM    
School of Materials Science and Engineering, Seoul National University, South Korea.
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MeSH Terms
Biocompatible Materials*
Calcium Fluoride / chemistry*
Cell Division
Cell Line
Durapatite / chemistry*
Materials Testing
Microscopy, Electron, Scanning
Osteoblasts / cytology
Zirconium / chemistry*
Reg. No./Substance:
0/Biocompatible Materials; 1306-06-5/Durapatite; 1314-23-4/zirconium oxide; 7440-67-7/Zirconium; 7789-75-5/Calcium Fluoride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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