Document Detail


Effect of the Ca2+ chelators EDTA and EGTA on sinoatrial-node activity and heart irritability.
MedLine Citation:
PMID:  6821017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the Ca-chelators EDTA and EGTA on sinoatrial activity and heart irritability was studied in dog experiments by perfusing the artery supplying the sinoatrial node. Beside the usual ECG recordings left and right atrial and left and right ventricular epicardial electrograms, His-bundle electrogram and the early activity of the sinoatrial node were recorded. In addition action potentials were recorded from the left auricle and right ventricle of the dog hearts. Local application around the sinoatrial and atrio-ventricular nodes of EDTA and EGTA caused sinus bradycardia and later sinus arrest within 1 min after introduction of the drugs. For substitution of the sinus rhythm junctional (seldom lower atrial) escape rhythm developed. One to two minutes later it was followed by atrial premature beats and even later atrial flutter and fibrillation could be recorded. In one third of the cases atrial fibrillation was followed by secondary ventricular fibrillation. Atrio-ventricular impulse conduction was prolonged in the av node by EDTA and EGTA. Atrial action potentials and the slow (Ca dependent) ventricular action potentials were depressed by EDTA and EGTA.
Authors:
F Solti; S Juhász-Nagy; V Kecskeméti; B Czakó; V Németh; V Kékesi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Academiae Scientiarum Hungaricae     Volume:  60     ISSN:  0001-6756     ISO Abbreviation:  Acta Physiol Acad Sci Hung     Publication Date:  1982  
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0371156     Medline TA:  Acta Physiol Acad Sci Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  155-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / chemically induced,  physiopathology*
Dogs
Edetic Acid / pharmacology*
Egtazic Acid / pharmacology*
Electrocardiography
Ethylene Glycols / pharmacology*
Heart / drug effects*,  physiology,  physiopathology
Sinoatrial Node / drug effects,  physiology*,  physiopathology
Chemical
Reg. No./Substance:
0/Ethylene Glycols; 60-00-4/Edetic Acid; 67-42-5/Egtazic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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