| Effect of the Ca antagonist nilvadipine on stroke occurrence or recurrence and extension of asymptomatic cerebral infarction in hypertensive patients with or without history of stroke (PICA Study). 1. Design and results at enrollment. | |
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MedLine Citation:
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PMID: 17596689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We examined the effect of a Ca antagonist (nilvadipine) on the occurrence or recurrence of symptomatic stroke in hypertensive patients with MRI-defined asymptomatic cerebral infarction (ACI), periventricular hyperintensity (PVH), and deep and subcortical white matter hyperintensity (DSWMH), with or without a history of stroke, and evaluated the effect of long-term treatment on the lesions. METHODS: Patients with hypertension and incidental ACI were divided into those with (group B, 235 patients) or without (group A, 181 patients) a history of symptomatic stroke, and were given nilvadipine 4-8 mg/day for 3 years. Primary evaluation points were occurrence of symptomatic ischemic stroke and development or extension of asymptomatic ischemic lesions. RESULTS: Male sex, hyperuricemia, diabetes, maximum diameter of infarction and PVH severity were stronger risk factors for group B. Numbers of cerebral infarctions were 31 +/- 28 (group A) and 42 +/- 32 (group B) at enrollment (p < 0.001). Infarctions were larger and located more frequently on the internal capsule, putamen, thalamus and brainstem in group B. The severity of PVH and DSWMH paralleled the number of cerebral infarctions in both groups. CONCLUSION: The study design and status of asymptomatic ischemic brain lesions in hypertensive subjects at enrollment are presented. |
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Authors:
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Yukito Shinohara; Hideo Tohgi; Shunsaku Hirai; Akiro Terashi; Yasuo Fukuuchi; Takenori Yamaguchi; Toshio Okudera |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-06-27 |
Journal Detail:
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Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 24 ISSN: 1015-9770 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-23 Completed Date: 2007-10-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 202-9 Citation Subset: IM |
Affiliation:
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Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tokyo, Japan. yshinoha@tachikawa-hosp.gr.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antihypertensive Agents / therapeutic use* Calcium Channel Blockers / therapeutic use* Cerebral Infarction / complications*, drug therapy, etiology, pathology Female Humans Hypertension / complications, drug therapy*, pathology Japan Magnetic Resonance Imaging Male Middle Aged Nifedipine / analogs & derivatives*, therapeutic use Recurrence Risk Factors Severity of Illness Index Stroke / etiology*, pathology, prevention & control Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 75530-68-6/nilvadipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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