| Effect of ca on the synthesis of deoxyribonucleic Acid in virulent and avirulent yersinia. | |
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MedLine Citation:
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PMID: 16557947 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Virulent and potentially virulent cells of Yersinia (Pasteurella) pestis produce virulence or V and W antigens (VW(+)) but remain static at 37 C during aeration in enriched Ca(2+)-deficient media containing 0.02 m Mg(2+). In this environment, which simulates mammalian intracellular fluid, VW(+) cells possessed a functional cytoplasmic membrane as judged by concentration of (14)C-isoleucine, release of (32)P, and consumption of oxygen at rates comparable to those of dividing cells cultivated with Ca(2+). Furthermore, rates of protein and ribonucleic acid synthesis were essentially identical in dividing and static VW(+) cells and in mutant VW(-) organisms. However, the rate of deoxyribonucleic acid (DNA) synthesis in static cells was about 10% of that observed in dividing organisms. Accordingly, bacteriostasis of VW(+) cells in the simulated intracellular environment is evidently caused by reactions directly associated with cessation of DNA synthesis rather than by alterations in the regulatory capacity of the cytoplasmic membrane. |
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Authors:
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G C Yang; R R Brubaker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection and immunity Volume: 3 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1971 Jan |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-06-29 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: United States |
Other Details:
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Languages: eng Pagination: 59-65 Citation Subset: - |
Affiliation:
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Department of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48823. |
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