Document Detail

Effect of CPAP on breathlessness perception in healthy subjects during methacholine induced bronchoconstriction.
MedLine Citation:
PMID:  11098298     Owner:  NLM     Status:  MEDLINE    
Application of continuous positive airway pressure (CPAP) in asthmatic patients decreases breathlessness (B). The effect of CPAP on induced bronchoconstriction was studied in healthy subjects. The changes in B were related to changes in lung function indices. In nine healthy volunteers, males aged 20-27 years, acute bronchoconstriction was induced by inhalation of 1 to 128 mg/ml methacholine (M). CPAP (0.5 kPa) was then applied for 1 min. It was followed by inhalation of albuterol. Forced expiratory volume in 1 s (FEV1) and vital capacity (VC) were measured by spirometry and end expiratory lung level (EELL), to derive inspiratory capacity (IC), by inductive plethysmography. B was assessed by Borg scale. After the maximal concentration of M, FEV1 decreased by 14% (p < 0.01) as compared to the control values and Borg score (BS) increased to 2.4 (p < 0.01). In 7 out of 9 subjects we found a significant (p < 0.05) correlation between the changes in FEV1 and BS. BS decreased during CPAP (p < 0.01) and it further decreased significantly after albuterol. There was no correlation between the changes in IC and FEV1 during bronchoconstriction, or between IC and BS during CPAP. In conclusion, in healthy subjects with induced bronchoconstriction CPAP decreased significantly BS, which was further improved by inhalation of albuterol. B was related to changes in FEV1 but not in IC.
S Kostianev; G Liistro; C Veriter; D Stanescu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica et pharmacologica Bulgarica     Volume:  24     ISSN:  0323-9950     ISO Abbreviation:  Acta Physiol Pharmacol Bulg     Publication Date:  1999  
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512568     Medline TA:  Acta Physiol Pharmacol Bulg     Country:  BULGARIA    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Pulmonary Laboratory, Cliniques Universitaires Saint Luc, Brussels, Belgium.
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MeSH Terms
Bronchoconstriction / drug effects*
Forced Expiratory Volume
Methacholine Chloride / pharmacology*
Positive-Pressure Respiration*
Reg. No./Substance:
62-51-1/Methacholine Chloride

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