Document Detail


Effect of CCK antibodies on food intake and weight gain in Zucker rats.
MedLine Citation:
PMID:  2408286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While exogenous administration of cholecystokinin (CCK) decreases food intake in many species, it has not been demonstrated conclusively that CCK is necessary for satiety to occur. In these experiments the role of CCK in eliciting satiety was further investigated by using endogenously produced and exogenously administered antibodies to CCK which were hypothesized to sequester circulating CCK. In the first experiment Zucker obese (n = 12, 192 +/- 16 g) and lean (n = 12, 152 +/- 11 g) male rats were administered CCK-8 conjugated to bovine serum albumin or bovine serum albumin by subcutaneous administration in Freund's adjuvant. Average percent binding of 125I-gastrin-17 by serum taken 4, 8 and 12 weeks after treatment initiation was increased (19.9 vs. 2.1, p less than 0.001) in rats treated with CCK conjugate than controls, and the increase was greater in lean (27.5 vs. 1.9) than in obese (12.2 vs. 2.2, p less than 0.001) rats. In lean, but not obese rats, average daily food intake and weight gain were increased (9 and 17% p less than 0.04 and p less than 0.02 respectively) in rats with CCK-AB compared with rats with no CCK-AB during the three months. Development of CCK-AB did not affect food intake response to exogenously administered CCK-8 or pancreas weight relative to body weight. In Experiment 2 increased food intakes of obese and lean rats 30 min after intraperitoneal injection of rabbit serum with CCK-AB were greater than those after intraperitoneal injection of rabbit serum without CCK-AB (1.92 vs. 1.41, g, p less than 0.007).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
C L McLaughlin; C A Baile; F C Buonomo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  34     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-06-28     Completed Date:  1985-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight*
Cholecystokinin / physiology*
DNA / metabolism
Eating*
Energy Metabolism
Male
Pancreas / physiology
RNA / metabolism
Rats
Rats, Zucker
Satiation / physiology
Chemical
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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